Retinal microvascular and microstructural alterations in the diagnosis of dermatomyositis: a new approach

Frontiers in Medicine

Medicine

Xu-Lin Liao¹  Qian Ling²  Miao-Miao Zang²  Hong Wei²  Chong-Gang Pei²  Bo-Zhi Huang²  Yi Shao²  Jie Zou²  San-Hua Xu²  Ping Ying² 

[1] Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China;Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China;

关键词: interstitial lung disease;    optical coherence tomography angiography;    retinal thickness;    vessel density;    dermatomyositis (DM);   

DOI  :  10.3389/fmed.2023.1164351

 received in 2023-02-12, accepted in 2023-05-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

PurposeTo study the relationship between fundus alterations, including retinal thickness and microvascular changes, and dermatomyositis (DM) using optical coherence tomography angiography (OCTA).MethodsA total of 16 patients with DM (32 eyes) and 16 healthy controls (HCs; 32 eyes) participated in this study. Based on the Early Treatment Diabetic Retinopathy Study subzones, OCTA fundus data were divided into different layers and regions for comparison.ResultsThe full retinal thickness (RT) in the inner nasal (IN), outer nasal (ON), inner inferior (II), and outer inferior (OI) regions of patients with DM was significantly lower than that of HCs (P < 0.001). The inner layer RT was also significantly lower in the IN, ON, II, and OI regions in patients with DM (P < 0.001). The outer layer RT was lower only in the II region in patients with DM compared to HCs (P < 0.001). The full RT of the II region was more sensitive to the pathological changes of disease since its ROC curve had an AUC of 0.9028, 95% CI: 0.8159–0.9898. Meanwhile, the superficial vessel density (SVD) of patients with DM was significantly lower in the IN, ON, II, and OI regions compared to HCs (P < 0.001). The AUC for region II was 0.9634 (95% CI: 0.9034–1.0), which indicated good diagnostic sensitivity.ConclusionOptical coherence tomography angiography can be used to evaluate relevant ocular lesions and monitor disease progression in patients with DM and interstitial lung disease.

【 授权许可】

Unknown   
Copyright © 2023 Huang, Ling, Xu, Zou, Zang, Liao, Wei, Ying, Pei and Shao.