The clinical relevance and prediction efficacy from therapy of tumor microenvironment related signature score in colorectal cancer

Frontiers in Oncology

Oncology

Lei Yu¹  Xiang Jun¹  Guiyu Wang¹  Shengnan Gao² 

[1] Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;

关键词: CRC;    therapy;    response;    TMERSS;    immune cell;    prediction;   

DOI  :  10.3389/fonc.2023.1123455

 received in 2022-12-14, accepted in 2023-04-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionAs the top 3 cancer in terms of incidence and mortality, the first-line treatment for CRC includes FOLFOX, FOLFIRI, Cetuximab or immunotherapy. However, the drug sensitivity of patients to regimens is different. There has been increasing evidence that immune components of TME can affect the sensitivity of patients to drugs. Therefore, it is necessary to define novo molecular subtypes of CRC based on TME immune components, and screen patients who are sensitive to the treatments, to make personalized therapy possible. MethodsWe analyzed the expression profiles and 197 TME-related signatures of 1775 patients using ssGSEA, univariate Cox proportional risk model and LASSO-Cox regression model, and defined a novo molecular subtype (TMERSS) of CRC. Simultaneously, we compared the clinicopathological factors, antitumor immune activity, immune cell abundance and differences of cell states in different TMERSS subtypes. In addition, patients sensitive to the therapy were screened out by correlation analysis between TMERSS subtypes and drug responses.ResultsCompared with low TMERSS subtype, high TMERSS subtype has a better outcome, which may be associated to higher abundance of antitumor immune cell in high TMERSS subtype. Our findings suggested that the high TMERSS subtype may have a higher proportion of respondents to Cetuximab agent and immunotherapy, while the low TMERSS subtype may be more suitable for treatment with FOLFOX and FOLFIRI regimens.DiscussionIn conclusion, the TMERSS model may provide a partial reference for the prognosis evaluation of patients, the prediction of drug sensitivity, and the implementation of clinical decision-making.

【 授权许可】

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Copyright © 2023 Jun, Gao, Yu and Wang