Altered resting-state functional connectivity patterns in late middle-aged and older adults with obstructive sleep apnea

Frontiers in Neurology

Neurology

Cynthia Thompson¹  Véronique Daneault¹  Jacques Montplaisir²  Marie-Ève Martineau-Dussault³  Julie Carrier³  Guillermo Martinez Villar³  Claire André³  Nadia Gosselin³  Nicola Andrea Marchi⁴  Jean-Marc Lina⁵  Katia Gagnon⁶  Chantal Lafond⁷  Danielle Gilbert⁸  Andrée-Ann Baril⁹ 

[1] Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l’Île-de-Montréal, Montréal, QC, Canada;Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l’Île-de-Montréal, Montréal, QC, Canada;Department of Psychiatry, Université de Montréal, Montréal, QC, Canada;Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l’Île-de-Montréal, Montréal, QC, Canada;Department of Psychology, Université de Montréal, Montréal, QC, Canada;Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l’Île-de-Montréal, Montréal, QC, Canada;Department of Psychology, Université de Montréal, Montréal, QC, Canada;Center for Investigation and Research in Sleep, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland;Laboratory for Research in Neuroimaging, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland;Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l’Île-de-Montréal, Montréal, QC, Canada;Département de Génie Electrique, École de Technologie Supérieure, Montréal, QC, Canada;Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l’Île-de-Montréal, Montréal, QC, Canada;Laboratory and Sleep Clinic, Hôpital en Santé Mentale Rivière-des-Prairies, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l’Île-de-Montréal, Montréal, QC, Canada;Department of Pulmonology, Hôpital du Sacré-Coeur de Montréal, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l’Île-de-Montréal, Montréal, QC, Canada;Department of Medicine, Université de Montréal, Montreal, QC, Canada;Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, QC, Canada;Department of Radiology, Hopital du Sacré-Coeur de Montréal, CIUSSS du Nord-de-l’Ile-de, Montréal, QC, Canada;Douglas Mental Health Institute, McGill University, Montréal, QC, Canada;

关键词: sleep-disordered breathing;    aging;    resting-state functional connectivity;    default mode network;    medial temporal lobe;    hippocampus;    medial prefrontal cortex;    posterior cingulate cortex;   

DOI  :  10.3389/fneur.2023.1215882

 received in 2023-05-02, accepted in 2023-06-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionObstructive sleep apnea (OSA) is increasingly recognized as a risk factor for cognitive decline, and has been associated with structural brain alterations in regions relevant to memory processes and Alzheimer’s disease. However, it is unclear whether OSA is associated with disrupted functional connectivity (FC) patterns between these regions in late middle-aged and older populations. Thus, we characterized the associations between OSA severity and resting-state FC between the default mode network (DMN) and medial temporal lobe (MTL) regions. Second, we explored whether significant FC changes differed depending on cognitive status and were associated with cognitive performance.MethodsNinety-four participants [24 women, 65.7 ± 6.9 years old, 41% with Mild Cognitive Impairment (MCI)] underwent a polysomnography, a comprehensive neuropsychological assessment and a resting-state functional magnetic resonance imaging (MRI). General linear models were conducted between OSA severity markers (i.e., the apnea-hypopnea, oxygen desaturation and microarousal indices) and FC values between DMN and MTL regions using CONN toolbox. Partial correlations were then performed between OSA-related FC patterns and (i) OSA severity markers in subgroups stratified by cognitive status (i.e., cognitively unimpaired versus MCI) and (ii) cognitive scores in the whole sample. All analyzes were controlled for age, sex and education, and considered significant at a p < 0.05 threshold corrected for false discovery rate.ResultsIn the whole sample, a higher apnea-hypopnea index was significantly associated with lower FC between (i) the medial prefrontal cortex and bilateral hippocampi, and (ii) the left hippocampus and both the posterior cingulate cortex and precuneus. FC patterns were not associated with the oxygen desaturation index, or micro-arousal index. When stratifying the sample according to cognitive status, all associations remained significant in cognitively unimpaired individuals but not in the MCI group. No significant associations were observed between cognition and OSA severity or OSA-related FC patterns.DiscussionOSA severity was associated with patterns of lower FC in regions relevant to memory processes and Alzheimer’s disease. Since no associations were found with cognitive performance, these FC changes could precede detectable cognitive deficits. Whether these FC patterns predict future cognitive decline over the long-term needs to be investigated.

【 授权许可】

Unknown   
Copyright © 2023 Martinez Villar, Daneault, Martineau-Dussault, Baril, Gagnon, Lafond, Gilbert, Thompson, Marchi, Lina, Montplaisir, Carrier, Gosselin and André.