Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases

Frontiers in Molecular Biosciences

Molecular Biosciences

David A. Gordon¹  Lei Zhao¹  Glen Banks¹  Morten A. Karsdal²  Alexander L. Reese-Petersen²  Federica Genovese² 

[1] Bristol Myers Squibb, New York, NJ, United States;Nordic Bioscience A/S, Herlev, Denmark;

关键词: fibrosis;    biomarkers;    heart failure;    collagen;    ECM;    extracellular matrix;    endotrophin;   

DOI  :  10.3389/fmolb.2023.1228232

 received in 2023-05-24, accepted in 2023-06-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

Extracellular matrix proteins harbor signaling domains that once released from the parent molecule can trigger cellular responses. One of these molecules is endotrophin, a type VI collagen derived fragment, whose circulatory levels have been associated to an increased risk of adverse outcome in heart failure with preserved ejection fraction (HFpEF). Here we show that the stimulation of human cardiac fibroblasts by endotrophin upregulates the synthesis of type I collagen, the main interstitial collagen that accumulates in the myocardium during fibrogenesis. These data provide a possible mechanistic explanation for the relation between circulating endotrophin levels and risk of outcome in HFpEF.

【 授权许可】

Unknown   
Copyright © 2023 Reese-Petersen, Genovese, Zhao, Banks, Gordon and Karsdal.