Toll-like receptors in cardiac hypertrophy

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Jimin Wu¹  Erdan Dong¹  Han Xiao¹  Yanan Zhang²  Zhanli Wang³ 

[1] Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China;NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University Third Hospital, Beijing, China;Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China;Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Beijing, China;Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China;Inner Mongolia Key Laboratory of Disease-Related Biomarkers, The Second Affiliated Hospital, Baotou Medical College, Baotou, China;Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China;NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University Third Hospital, Beijing, China;Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China;Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Beijing, China;Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China;Department of Clinical Laboratory, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China;Inner Mongolia Key Laboratory of Disease-Related Biomarkers, The Second Affiliated Hospital, Baotou Medical College, Baotou, China;Department of Clinical Laboratory, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China;

关键词: cardiac hypertrophy;    toll-like receptor;    innate immune;    inflammation;    signaling pathway;   

DOI  :  10.3389/fcvm.2023.1143583

 received in 2023-01-13, accepted in 2023-03-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRRs) that can identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). TLRs play an important role in the innate immune response, leading to acute and chronic inflammation. Cardiac hypertrophy, an important cardiac remodeling phenotype during cardiovascular disease, contributes to the development of heart failure. In previous decades, many studies have reported that TLR-mediated inflammation was involved in the induction of myocardium hypertrophic remodeling, suggesting that targeting TLR signaling might be an effective strategy against pathological cardiac hypertrophy. Thus, it is necessary to study the mechanisms underlying TLR functions in cardiac hypertrophy. In this review, we summarized key findings of TLR signaling in cardiac hypertrophy.

【 授权许可】

Unknown   
© 2023 Zhang, Wu, Dong, Wang and Xiao.