Correspondence between BOLD fMRI task response and cerebrovascular reactivity across the cerebral cortex

Frontiers in Physiology

Physiology

Jacinta L. Specht¹  G. Bruce Pike¹  R. Marc Lebel²  M. Ethan MacDonald³  Erin L. Mazerolle⁴  Rebecca J. Williams⁵ 

[1] Department of Clinical Neuroscience, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;GE HealthCare, Calgary, AB, Canada;Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;Department of Biomedical Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada;Department of Electrical and Software Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada;Departments of Psychology and Computer Science, St. Francis Xavier University, Antigonish, NS, Canada;Faculty of Health, School of Human Services, Charles Darwin University, Darwin, NT, Australia;

关键词: BOLD;    cerebrovascular reactivity;    hypercapnia;    functional magnet resonance imaging (fMRI);    cerebral blood blow;    vascular physiology;    attention;    cognition;   

DOI  :  10.3389/fphys.2023.1167148

 received in 2023-02-16, accepted in 2023-04-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

BOLD sensitivity to baseline perfusion and blood volume is a well-acknowledged fMRI confound. Vascular correction techniques based on cerebrovascular reactivity (CVR) might reduce variance due to baseline cerebral blood volume, however this is predicated on an invariant linear relationship between CVR and BOLD signal magnitude. Cognitive paradigms have relatively low signal, high variance and involve spatially heterogenous cortical regions; it is therefore unclear whether the BOLD response magnitude to complex paradigms can be predicted by CVR. The feasibility of predicting BOLD signal magnitude from CVR was explored in the present work across two experiments using different CVR approaches. The first utilized a large database containing breath-hold BOLD responses and 3 different cognitive tasks. The second experiment, in an independent sample, calculated CVR using the delivery of a fixed concentration of carbon dioxide and a different cognitive task. An atlas-based regression approach was implemented for both experiments to evaluate the shared variance between task-invoked BOLD responses and CVR across the cerebral cortex. Both experiments found significant relationships between CVR and task-based BOLD magnitude, with activation in the right cuneus (R2 = 0.64) and paracentral gyrus (R2 = 0.71), and the left pars opercularis (R2 = 0.67), superior frontal gyrus (R2 = 0.62) and inferior parietal cortex (R2 = 0.63) strongly predicted by CVR. The parietal regions bilaterally were highly consistent, with linear regressions significant in these regions for all four tasks. Group analyses showed that CVR correction increased BOLD sensitivity. Overall, this work suggests that BOLD signal response magnitudes to cognitive tasks are predicted by CVR across different regions of the cerebral cortex, providing support for the use of correction based on baseline vascular physiology.

【 授权许可】

Unknown   
Copyright © 2023 Williams, Specht, Mazerolle, Lebel, MacDonald and Pike.