Cigarette smoking and risk of suicide in bipolar disorder: a systematic review

Frontiers in Psychiatry

Psychiatry

Patricio Molero¹  Jesús García-Jiménez²  Francisco José Gómez-Sierra²  Luis Gutiérrez-Rojas³  Braulio Girela-Serrano⁴  Paula Moreno-Merino⁵  Alicia Martínez-Hortelano⁶ 

[1] Department of Psychiatry and Medical Psychology, University Clinic of Navarra, Pamplona, Spain;Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain;Department of Psychiatry, San Cecilio University Hospital, Granada, Spain;Department of Psychiatry, San Cecilio University Hospital, Granada, Spain;Psychiatry and Neuroscience Research Group (CTS-549), Neuroscience Institute, University of Granada, Granada, Spain;Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, United Kingdom;Mental Health Unit at Estepona, Virgen de la Victoria Hospital, Málaga, Spain;Mental Health Unit at La Mata, University Hospital of Torrevieja, Alicante, Spain;

关键词: smoking;    bipolar disorder;    tobacco use disorder;    nicotine dependence;    suicide;    suicidal ideation;   

DOI  :  10.3389/fpsyt.2023.1179733

 received in 2023-03-04, accepted in 2023-05-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveBipolar disorder (BD) is a highly prevalent, chronic and recurrent mental illness. The smoking rates in patients with BD are much higher than those of the general population, and BD is associated with an increased risk of suicide. An association between smoking and suicidal behavior has been found in the general population, this systematic review examines whether there is evidence of an association between smoking and suicide behavior in patients with BD.MethodA database search was carried out in Medline, Embase, The Cochrane Library, Scopus, and Web of Science, updated until December 31st, 2021, according to the 2020 PRISMA guidelines. We identified prospective and retrospective studies that included patients diagnosed with BD types I, II, and not otherwise specified, and in which smoking and suicidal behavior were correlated. Articles that focused exclusively on other mental disorders were excluded. The Ottawa-Newcastle scale was used to assess the methodological quality of the included articles.ResultsFifteen articles (n = 7,395) met all the inclusion criteria. In nine of these articles, the authors found an association between smoking and suicidal behavior in BD, while in the remaining six articles, this association was not found. A great deal of variability was observed between articles, particularly in the measurement of suicidal behavior and tobacco consumption. The risk of bias, as assessed by the NOS, was high for most of the included articles, except for two papers, whose risk was low.ConclusionIt was not possible to establish a clear relationship between tobacco use and the risk of suicide in BD patients due to the heterogeneity of the articles included in this systematic review, which had different sample sizes and methodological issues. However, both conditions are highly prevalent and have a negative impact on the prognosis of BD. Therefore, a systematic approach is needed, based on accurate measurement of a patient’s smoking habits and their risk of suicidal behavior, in order to establish an appropriate therapeutic plan.Additional informationThis research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors and was registered on PROSPERO with the CRD42022301570 on January 21th 2022.

【 授权许可】

Unknown   
Copyright © 2023 García-Jiménez, Gómez-Sierra, Martínez-Hortelano, Moreno-Merino, Girela-Serrano, Molero and Gutiérrez-Rojas.