Notch signaling as a master regulator of adult neurogenesis

Frontiers in Neuroscience

Neuroscience

Aikaterini Lampada¹  Verdon Taylor² 

[1] Department of Biomedicine, University of Basel, Basel, Switzerland;null;

关键词: Notch;    neural stem cells;    neurogenesis;    subventricular zone;    dentate gyrus;   

DOI  :  10.3389/fnins.2023.1179011

 received in 2023-03-03, accepted in 2023-06-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

Neurogenesis ceases in most regions of the mammalian brain before or shortly after birth, however, in a few restricted brain regions, the production of new neurons proceeds into adulthood. Neural stem cells (NSCs) in these neurogenic zones are integrated into niches that control their activity and fate. Most stem cells in the adult brain are mitotically inactive and these cells can remain quiescent for months or even years. One of the key questions is what are the molecular mechanisms that regulate NSC maintenance and differentiation. Notch signaling has been shown to be a critical regulator of stem cell activity and maintenance in many tissues including in the nervous system. In this mini-review we discuss the roles of Notch signaling and the functions of the different Notch receptors and ligands in regulating neurogenesis in the adult murine brain. We review the functions of Notch signaling components in controlling NSC quiescence and entry into cell cycle and neurogenesis.

【 授权许可】

Unknown   
Copyright © 2023 Lampada and Taylor.