Maternal and paternal tuberculosis is associated with increased asthma and respiratory symptoms in their offspring: a study from Northern Europe

Frontiers in Allergy

Allergy

Ane Johannessen¹  Cecilie Svanes²  Sanjay Gyawali²  Juan Pablo López-Cervantes²  Tehmina Mustafa³  Christer Janson⁴  Lars Modig⁵  Vivi Schlünssen⁶  Thorarinn Gislason⁷  Rain Jögi⁸  Mathias Holm⁹ 

[1] Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway;Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway;Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway;Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway;Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway;Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden;Department of Public Health and Clinical Medicine, Sustainable Health, Umeå University, Umeå, Sweden;Department of Public Health, Research Unit for Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark;Faculty of Medical, University of Iceland, Reykjavik, Iceland;Department of Sleep, Landspitali University Hospital, Reykjavik, Iceland;Lung Clinic, Tartu University Hospital, Tartu, Estonia;Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;

关键词: asthma;    tuberculosis;    epigenetic;    offspring asthma;    generational study;   

DOI  :  10.3389/falgy.2023.1193141

 received in 2023-03-24, accepted in 2023-05-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundGiven the profound impact of tuberculosis (TB) on immunity and given murine studies suggesting that infections may influence immunity across generations, we hypothesize that parental TB might impact health and disease in future offspring.ObjectiveThis study investigated the impact of maternal and paternal TB on offspring asthma and respiratory symptoms.MethodsWe included data from the third follow-up of the Respiratory Health in Northern Europe study (RHINE). Information on own asthma status, asthma-like symptoms and other respiratory symptoms, as well as information about parental TB and asthma, were collected using standardized questionnaires. The associations between parental TB and RHINE participants' asthma and respiratory symptoms were analyzed using multiple logistic regression, with adjustment for parental education, smoking habits and asthma.ResultsOf 8,323 study participants, 227 (2.7%) reported only paternal TB, 282 (3.4%) only maternal TB, and 33 (0.4%) reported that both parents had TB. We found a higher risk of asthma (aOR: 1.29, 95% CI: 1.05–1.57) in offspring with a history of parental TB as compared to offspring without parental TB., Parental TB was significantly associated with allergic asthma in offspring (aOR: 1.58, 95% CI: 1.29–2.05), while no significant association between parental TB and asthma without allergy (aOR: 1.00, 95% CI: 0.76–1.32) in offspring was observed.ConclusionResults from this study indicate that parental TB might be a risk factor for offspring's asthma and respiratory symptoms. We raise the hypothesis that the immunological impact of infections might be transmitted to influence offspring phenotype in humans.

【 授权许可】

Unknown   
© 2023 Gyawali, López-Cervantes, Johannessen, Gislason, Holm, Janson, Jögi, Modig, Schlünssen, Mustafa and Svanes.