Association of serum lipids with inflammatory bowel disease: a systematic review and meta-analysis

Frontiers in Medicine

Medicine

Jingyi Hu¹  Lei Zhu¹  Weiyang Li¹  Hong Shen¹  Feng Xu¹  Hongxin Chen¹  Yizhou Lu¹ 

[1] Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China;The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, China;

关键词: inflammatory bowel disease;    Cronh’s disease;    ulcerative disease;    serum lipids;    meta-analysis;   

DOI  :  10.3389/fmed.2023.1198988

 received in 2023-04-04, accepted in 2023-08-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundSerum lipid levels seem to be abnormal in Inflammatory bowel disease (IBD). However, the specific manifestation of abnormal serum lipid levels in IBD are heterogeneous among studies and have not been sufficiently determined yet.MethodsPubMed, EMBASE, and Cochrane Library databases were searched. Serum lipid levels were compared between IBD patients and Health individuals, Crohn’s (CD) and ulcerative colitis (UC), active and inactive, mild and non-mild patients, respectively. Meta-analyses were performed by using a random-effect model. Weight mean difference (WMD) with 95% confidence intervals (CIs) were calculated.ResultsOverall, 53 studies were included. Compared with healthy controls, IBD patients had significantly lower TC (WMD = −0.506, 95%CI = −0.674 to −0.338, p < 0.001), HDL-c (WMD = −0.122, 95%CI = −0.205 to −0.039, p = 0.004), and LDL-c (WMD = −0.371, 95%CI = −0.547 to −0.194, p < 0.001) levels. CD groups had a significantly lower TC (WMD = −0.349, 95%CI = −0.528 to −0.170, p < 0.0001) level as compared to UC groups. Active IBD and non-mild UC groups had significantly lower TC (WMD = −0.454, 95%CI = −0.722 to −0.187, p = 0.001) (WMD =0.462, 95%CI = 0.176 to 0.748, p = 0.002) and LDL-c (WMD = −0.225, 95%CI = −0.445 to −0.005, p = 0.045) (WMD =0.346, 95%CI = 0.084–0.609, p = 0.010) levels as compared to inactive IBD and mild UC groups, respectively.ConclusionThe overall level of serum lipids in IBD patients is lower than that of healthy individuals and is negatively associated with disease severity.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022383885.

【 授权许可】

Unknown   
Copyright © 2023 Chen, Li, Hu, Xu, Lu, Zhu and Shen.