Numerical hemolysis performance evaluation of a rotary blood pump under different speed modulation profiles

Frontiers in Physiology

Physiology

Huan Lei¹  Qipeng Li¹  Yang Fu¹  Feng Huang²  Xiaodong Ruan³  Shunv Ying⁴ 

[1] School of Mechanical and Energy Engineering, Zhejiang University of Science and Technology, Hangzhou, China;School of Mechanical and Energy Engineering, Zhejiang University of Science and Technology, Hangzhou, China;State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China;State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China;Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China;

关键词: rotary blood pump;    hemolysis;    numerical evaluation;    speed modulation;    computational fluid dynamics;   

DOI  :  10.3389/fphys.2023.1116266

 received in 2022-12-05, accepted in 2023-01-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

Introduction: Speed modulation methods have been studied and even used clinically to create extra pulsation in the blood circulatory system with the assistance of a continuous flow rotary blood pump. However, fast speed variations may also increase the hemolysis potential inside the pump.Methods: This study investigates the hemolysis performance of a ventricular assist rotary blood pump under sinusoidal, square, and triangular wave speed modulation profiles using the computational fluid dynamics (CFD) method. The CFD boundary pressure conditions of the blood pump were obtained by combining simulations with the pump’s mathematical model and a complete cardiovascular lumped parameter model. The hemolysis performance of the blood pump was quantified by the hemolysis index (HI) calculated from a Eulerian scalar transport equation.Results: The HI results were obtained and compared with a constant speed condition when the blood pump was run under three speed profiles. The speed modulations were revealed to slightly affect the pump hemolysis, and the hemolysis differences between the different speed modulation profiles were insignificant.Discussion: This study suggests that speed modulations could be a feasible way to improve the flow pulsatility of rotary blood pumps while not increasing the hemolysis performance.

【 授权许可】

Unknown   
Copyright © 2023 Huang, Lei, Ying, Fu, Li and Ruan.