Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer

Frontiers in Immunology

Immunology

Gang Liu¹  Maorun Zhang¹  Xiaoping Li¹  Jiahua Yang¹  Qi Zhang¹ 

[1] Deparment of General Surgery, Tianjin Medical University General Hospital, Tianjin, China;

关键词: ulcerative colitis;    colitis-associated colorectal cancer;    macrophage infiltration;    macrophage polarization;    macrophage;   

DOI  :  10.3389/fimmu.2023.1103617

 received in 2022-11-20, accepted in 2023-03-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

Colitis-associated colorectal cancer is the most serious complication of ulcerative colitis. Long-term chronic inflammation increases the incidence of CAC in UC patients. Compared with sporadic colorectal cancer, CAC means multiple lesions, worse pathological type and worse prognosis. Macrophage is a kind of innate immune cell, which play an important role both in inflammatory response and tumor immunity. Macrophages are polarized into two phenotypes under different conditions: M1 and M2. In UC, enhanced macrophage infiltration produces a large number of inflammatory cytokines, which promote tumorigenesis of UC. M1 polarization has an anti-tumor effect after CAC formation, whereas M2 polarization promotes tumor growth. M2 polarization plays a tumor-promoting role. Some drugs have been shown to that prevent and treat CAC effectively by targeting macrophages.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Li, Zhang, Yang and Liu