Lamin B1 as a key modulator of the developing and aging brain

Frontiers in Cellular Neuroscience

Neuroscience

Irene Neri¹  Antonietta Fazio¹  Foteini-Dionysia Koufi¹  Lucia Manzoli¹  Sara Mongiorgi¹  Giulia Ramazzotti¹  Isabella Rusciano¹  Stefano Ratti¹  Maria Vittoria Marvi¹  Ilaria Cani²  Pietro Cortelli³  Elisa Giorgio⁴  Minkyung Shin⁵  Yoichi Kosodo⁵ 

[1] Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), Anatomy Centre, University of Bologna, Bologna, Italy;Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy;Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy;IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy;Department of Molecular Medicine, University of Pavia, Pavia, Italy;Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy;Korea Brain Research Institute (KBRI), Daegu, Republic of Korea;

关键词: lamin B1;    nuclear lamina;    glia;    astrocytes;    neurogenesis;    neurons;    brain development;    aging brain;   

DOI  :  10.3389/fncel.2023.1263310

 received in 2023-07-19, accepted in 2023-08-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Lamin B1 is an essential protein of the nuclear lamina that plays a crucial role in nuclear function and organization. It has been demonstrated that lamin B1 is essential for organogenesis and particularly brain development. The important role of lamin B1 in physiological brain development and aging has only recently been at the epicenter of attention and is yet to be fully elucidated. Regarding the development of brain, glial cells that have long been considered as supporting cells to neurons have overturned this representation and current findings have displayed their active roles in neurogenesis and cerebral development. Although lamin B1 has increased levels during the differentiation of the brain cells, during aging these levels drop leading to senescent phenotypes and inciting neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. On the other hand, overexpression of lamin B1 leads to the adult-onset neurodegenerative disease known as Autosomal Dominant Leukodystrophy. This review aims at highlighting the importance of balancing lamin B1 levels in glial cells and neurons from brain development to aging.

【 授权许可】

Unknown   
Copyright © 2023 Koufi, Neri, Ramazzotti, Rusciano, Mongiorgi, Marvi, Fazio, Shin, Kosodo, Cani, Giorgio, Cortelli, Manzoli and Ratti.