Longitudinal change of inhibitory control functional connectivity associated with the development of heavy alcohol drinking

Frontiers in Psychology

Psychology

Marcos Uceta¹  Fernando Maestú²  Danylyna Shpakivska-Bilan²  Alberto Del Cerro-León²  Luis F. Antón-Toro³  Ricardo Bruña⁴  Luis M. García-Moreno⁵ 

[1] Center for Cognitive and Computational Neuroscience (C3N), Complutense University of Madrid (UCM), Madrid, Spain;Department of Cellular Biology, Faculty of Biology, Complutense University of Madrid (UCM), Madrid, Spain;Center for Cognitive and Computational Neuroscience (C3N), Complutense University of Madrid (UCM), Madrid, Spain;Department of Experimental Psychology, Faculty of Psychology, Complutense University of Madrid (UCM), Madrid, Spain;Center for Cognitive and Computational Neuroscience (C3N), Complutense University of Madrid (UCM), Madrid, Spain;Department of Psychology, University Camilo José Cela (UCJC), Madrid, Spain;Center for Cognitive and Computational Neuroscience (C3N), Complutense University of Madrid (UCM), Madrid, Spain;Department of Radiology, Faculty of Medicine, Complutense University of Madrid (UCM), Madrid, Spain;Department of Psychobiology and Methodology in Behavioral Science, Faculty of Psychology, Complutense University of Madrid (UCM), Madrid, Spain;

关键词: binge drinking;    functional connectivity;    MEG;    inhibitory control;    adolescence;    heavy drinking;   

DOI  :  10.3389/fpsyg.2023.1069990

 received in 2022-10-14, accepted in 2023-01-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionHeavy drinking (HD) prevalent pattern of alcohol consumption among adolescents, particularly concerning because of their critical vulnerability to the neurotoxic effects of ethanol. Adolescent neurodevelopment is characterized by critical neurobiological changes of the prefrontal, temporal and parietal regions, important for the development of executive control processes, such as inhibitory control (IC). In the present Magnetoencephalography (MEG) study, we aimed to describe the relationship between electrophysiological Functional Connectivity (FC) during an IC task and HD development, as well as its impact on functional neuromaturation.MethodsWe performed a two-year longitudinal protocol with two stages. In the first stage, before the onset of HD, we recorded brain electrophysiological activity from a sample of 67 adolescents (mean age = 14.6 ± 0.7) during an IC task. Alcohol consumption was measured using the AUDIT test and a semi-structured interview. Two years later, in the second stage, 32 of the 67 participants (mean age 16.7 ± 0.7) completed a similar protocol. As for the analysis in the first stage, the source-space FC matrix was calculated, and then, using a cluster-based permutation test (CBPT) based on Spearman’s correlation, we calculated the correlation between the FC of each cortical source and the number of standard alcohol units consumed two years later. For the analysis of longitudinal change, we followed a similar approach. We calculated the symmetrized percentage change (SPC) between FC at both stages and performed a CBPT analysis, analyzing the correlation between FC change and the level of alcohol consumed in a regular session.ResultsThe results revealed an association between higher beta-band FC in the prefrontal and temporal regions and higher consumption years later. Longitudinal results showed that greater future alcohol consumption was associated with an exacerbated reduction in the FC of the same areas.DiscussionThese results underline the existence of several brain functional differences prior to alcohol misuse and their impact on functional neuromaturation.

【 授权许可】

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Copyright © 2023 Antón-Toro, Shpakivska-Bilan, Del Cerro-León, Bruña, Uceta, García-Moreno and Maestú.