TME-targeted approaches of brain metastases and its clinical therapeutic evidence

Frontiers in Immunology

Immunology

Hari Siva Sai Sala¹  Yong Liu¹  Ibrar Muhammad Khan¹  Syed Shams ul Hassan²  Nazir Muhammad Khan³  Muhammad Azhar Ud Din⁴  Safir Ullah Khan⁵  Samiullah Khan⁶  Munir Ullah Khan⁷ 

[1] Anhui Province Key Laboratory of Embryo Development and Reproduction Regulation, Anhui Province Key Laboratory of Environmental Hormone and Reproduction, School of Biological and Food Engineering, Fuyang Normal University, Fuyang, China;Department of Natural Product Chemistry, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China;Department of Zoology, University of Science and Technology, Bannu, Pakistan;Faculty of Pharmacy, Gomal University, Dera Ismail Khan, KPK, Pakistan;Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, China;Institute of Entomology, Guizhou University, Scientific Observing and Experimental Station of Crop Pests, Guiyang, Ministry of Agricultural and Affairs, Guiyang, China;MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China;

关键词: brain metastases;    tumor microenvironment;    central nervous system barrier;    immunotherapy;    molecular mechanism;   

DOI  :  10.3389/fimmu.2023.1131874

 received in 2022-12-26, accepted in 2023-04-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

The tumor microenvironment (TME), which includes both cellular and non-cellular elements, is now recognized as one of the major regulators of the development of primary tumors, the metastasis of which occurs to specific organs, and the response to therapy. Development of immunotherapy and targeted therapies have increased knowledge of cancer-related inflammation Since the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCB) limit immune cells from entering from the periphery, it has long been considered an immunological refuge. Thus, tumor cells that make their way “to the brain were believed to be protected from the body’s normal mechanisms of monitoring and eliminating them. In this process, the microenvironment and tumor cells at different stages interact and depend on each other to form the basis of the evolution of tumor brain metastases. This paper focuses on the pathogenesis, microenvironmental changes, and new treatment methods of different types of brain metastases. Through the systematic review and summary from macro to micro, the occurrence and development rules and key driving factors of the disease are revealed, and the clinical precision medicine of brain metastases is comprehensively promoted. Recent research has shed light on the potential of TME-targeted and potential treatments for treating Brain metastases, and we’ll use that knowledge to discuss the advantages and disadvantages of these approaches.

【 授权许可】

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Copyright © 2023 Khan, Khan, Sala, Khan, Ud Din, Khan, Hassan, Khan and Liu