Urinary KIM-1 is not correlated with gestational age among 5-year-old children born prematurely

Frontiers in Pediatrics

Pediatrics

Laura Torres-Canchala¹  Adriana Villegas²  Oscar Ramirez³  Juan C. Arias⁴  Michael Ferguson⁵  Jaime M. Restrepo⁶  Joseph V. Bonventre⁷  Guido Filler⁸ 

[1] Centro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia;Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;Department of Pathology and Laboratory Medicine, Fundación Valle del Lili, Cali, Colombia;Department of Pediatrics, Centro Médico Imbanaco de Cali, Cali, Colombia;Fundación POHEMA, Cali, Colombia;Kangaroo Mother House Alfa, Cali, Colombia;Pediatric Nephrology Service, Boston Children Hospital, Boston, United States;Pediatric Nephrology Service, Fundación Valle del Lili, Cali, Colombia;Renal Division, Brigham and Women's Hospital, Boston, MA, United States;The, Lilibeth Caberto Kidney Clinical Research Unit, Western University, London, ON, Canada;The, Lilibeth Caberto Kidney Clinical Research Unit, Western University, London, ON, Canada;

关键词: KIM-1 (kidney injury molecule 1);    gestational age (GA);    renal volume z-scores;    specific gravity (density);    prematurity and low birth weight;   

DOI  :  10.3389/fped.2023.1038206

 received in 2022-09-06, accepted in 2023-01-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundPreterm birth is associated with decreased nephron endowment. Currently, there is no reliable non-invasive biomarker to identify or monitor decreased nephron number in at-risk patients. Urinary Kidney Injury Molecule-1 (KIM-1) is a biomarker of acute and chronic renal injury. We measured urinary KIM-1 among a wide array of other potential biomarkers.MethodsWe conducted an ambispective cohort study of 5-years-old children born prematurely and healthy controls identified from city schools. Detailed anthropometrics, renal ultrasound dimensions, and biochemical parameters were measured. Urinary KIM-1 was measured using Luminex® technology. Age independent z-scores were calculated and compared. Spearman correlations were used for estimating the association between measures and KIM-1.ResultsWe enrolled 129 children, 97 (75.2%) born pre-term and 32 (24.8%) healthy controls born at full-term. Pre-term patients had significantly lower weight and body surface area than controls. Pre-term patients and controls did not differ in current age, sex, race, height, blood pressure, urinary sodium, fractional sodium excretion, serum creatinine and estimated GFR. All spearman correlation between KIM-1 and gestational age, renal and serum measurements were weak without statistical significanceConclusionIn 5-year-old children born prematurely, KIM-1 was not correlated with gestational age. Further prospective studies need to confirm this finding.

【 授权许可】

Unknown   
© 2023 Restrepo, Torres-Canchala, Bonventre, Arias, Ferguson, Villegas, Ramirez and Filler.