期刊论文详细信息
Frontiers in Endocrinology
Exercise for prevention of falls and fall-related injuries in neurodegenerative diseases and aging-related risk conditions: a meta-analysis
Endocrinology
Yu Sun1  Haocheng Xu1  Xin Tian1  Nan Li1  Renqing Zhao1  Xin Zhang1  Xun Sun1  Feifei Feng2 
[1] College of Physical Education, Yangzhou University, Yangzhou, China;College of Physical Education, Yangzhou University, Yangzhou, China;School of Humanities and Education, Guangzhou Nanyang Polytechnic College, Guangzhou, China;
关键词: falls;    fall-related injuries;    neurodegenerative diseases;    aging;    exercise;   
DOI  :  10.3389/fendo.2023.1187325
 received in 2023-03-15, accepted in 2023-06-21,  发布年份 2023
来源: Frontiers
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【 摘 要 】

IntroductionNeurodegenerative diseases often cause motor and cognitive deterioration that leads to postural instability and motor impairment, while aging-associated frailty frequently results in reduced muscle mass, balance, and mobility. These conditions increase the risk of falls and injuries in these populations. This study aimed to determine the effects of exercise on falls and consequent injuries among individuals with neurodegenerative diseases and frail aging people.MethodsElectronic database searches were conducted in PubMed, Cochrane Library, SportDiscus, and Web of Science up to 1 January 2023. Randomized controlled trials that reported the effects of exercise on falls and fall-related injuries in neurodegenerative disease and frail aging people were eligible for inclusion. The intervention effects for falls, fractures, and injuries were evaluated by calculating the rate ratio (RaR) or risk ratio (RR) with 95% confidence interval (CI).ResultsSixty-four studies with 13,241 participants met the inclusion criteria. Exercise is effective in reducing falls for frail aging people (RaR, 0.75; 95% CI, 0.68–0.82) and participants with ND (0.53, 0.43–0.65) [dementia (0.64, 0.51–0.82), Parkinson’s disease (0.49, 0.39–0.69), and stroke survivors (0.40, 0.27–0.57)]. Exercise also reduced fall-related injuries in ND patients (RR, 0.66; 95% CI, 0.48–0.90) and decreased fractures (0.63, 0.41–0.95) and fall-related injuries (0.89, 0.84–0.95) among frail aging people. For fall prevention, balance and combined exercise protocols are both effective, and either short-, moderate-, or long-term intervention duration is beneficial. More importantly, exercise only induced a very low injury rate per participant year (0.007%; 95% CI, 0–0.016) and show relatively good compliance with exercise (74.8; 95% CI, 69.7%–79.9%).DiscussionExercise is effective in reducing neurodegenerative disease- and aging-associated falls and consequent injuries, suggesting that exercise is an effective and feasible strategy for the prevention of falls.

【 授权许可】

Unknown   
Copyright © 2023 Feng, Xu, Sun, Zhang, Li, Sun, Tian and Zhao

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