Mendelian randomization study reveals a causal relationship between coronary artery disease and cognitive impairment

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Fenglan Liu¹  Yue Liu²  Yanfei Liu³  Qing Wang³  Fengqin Xu³  Shihan Xu³ 

[1] Graduate School of Guangdong Pharmaceutical University, Guangzhou, China;National Clinical Research Center for TCM Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China;The Second Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China;National Clinical Research Center for TCM Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China;

关键词: causal effect;    genome-wide association studies;    mendelian randomization;    cognitive impairment;    coronary artery disease;   

DOI  :  10.3389/fcvm.2023.1150432

 received in 2023-01-27, accepted in 2023-05-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundGrowing evidence suggests that Coronary artery disease (CAD) is associated with cognitive impairment. However, these results from observational studies was not entirely consistent, with some detecting no such association. And it is necessary to explore the causal relationship between CAD and cognitive impairment.ObjectiveWe aimed to explore the potential causal relationship between CAD and cognitive impairment by using bidirectional two-sample mendelian randomization (MR) analyses.MethodsInstrument variants were extracted according to strict selection criteria. And we used publicly available summary-level GWAS data. Five different methods of MR [random-effect inverse-variance weighted (IVW), MR Egger, weighted median, weighted mode and Wald ratio] were used to explore the causal relationship between CAD and cognitive impairment.ResultsThere was little evidence to support a causal effect of CAD on cognitive impairment in the forward MR analysis. In the reverse MR analyses, We detect causal effects of fluid intelligence score (IVW: β = −0.12, 95% CI of −0.18 to −0.06, P = 6.8 × 10−5), cognitive performance (IVW: β = −0.18, 95% CI of −0.28 to −0.08, P = 5.8 × 10−4) and dementia with lewy bodies (IVW: OR = 1.07, 95% CI of 1.04–1.10, P = 1.1 × 10−5) on CAD.ConclusionThis MR analysis provides evidence of a causal association between cognitive impairment and CAD. Our findings highlight the importance of screening for coronary heart disease in patients of cognitive impairment, which might provide new insight into the prevention of CAD. Moreover, our study provides clues for risk factor identification and early prediction of CAD.

【 授权许可】

Unknown   
© 2023 Xu, Liu, Wang, Liu, Xu and Liu.