Cognition and BDNF levels in prediabetes and diabetes: A mediation analysis of a cross-sectional study

Frontiers in Endocrinology

Endocrinology

Ozge Pasin¹  Betul Sumbul-Sekerci²  Zeynep Irem Yuksel-Salduz³  Abdusselam Sekerci⁴  Ezgi Durmus⁵ 

[1] Department of Biostatistics, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Türkiye;Department of Clinical Pharmacy, Faculty of Pharmacy, Bezmialem Vakif University, Istanbul, Türkiye;Department of Family Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Türkiye;Department of Internal Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Türkiye;Department of Medical Biochemistry, Bezmialem Vakif University, Istanbul, Türkiye;Health Sciences Institute, Bezmialem Vakif University, Istanbul, Türkiye;

关键词: diabetes;    cognitive impairment;    BDNF;    mediation analysis;    prediabetes;   

DOI  :  10.3389/fendo.2023.1120127

 received in 2022-12-09, accepted in 2023-02-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

AimClinical and epidemiological studies suggest links between dementias and Type 2 diabetes (T2DM). The underlying mechanisms of diabetes-related cognitive impairment are largely unknown. This study aims to investigate the role of BDNF in cognitive impairment in prediabetes and T2DM.MethodsThe study included 68 patients with prediabetes (preDM), 96 patients with T2DM, and 65 healthy controls. The cognitive function of the patients was evaluated with the Montreal Cognitive Assessment (MoCA) test and serum BDNF levels were measured by Elisa. The MoCA scores and BDNF levels were compared between diabetes groups after adjusting for age, gender, and education using ANCOVA. The role of BDNF in the diabetes-related cognitive impairment was investigated through mediation analysis.ResultsPatients with T2DM had significantly lower cognitive performance, particularly in memory. Diabetes was found to be a predictor of both cognitive impairment and BDNF levels. A significant increase in serum BDNF levels was observed in patients with T2DM. However, the mediator role of BDNF in the pathology of cognitive impairment in diabetes was not determined.ConclusionCognitive impairment is prevalent in patients with T2DM and should be included in routine screening for complications. The results of the mediation analysis suggest that although BDNF is a biomarker affected by T2DM and cognition, it does not play a mediator role between cognitive impairment and diabetes.

【 授权许可】

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Copyright © 2023 Sumbul-Sekerci, Sekerci, Pasin, Durmus and Yuksel-Salduz