Hemodynamic Differences Between Basilar Artery Fenestration and Normal Vertebrobasilar Artery: A Pilot Study

Frontiers in Neurology

Neurology

Renjie Yang¹  Xuesong Bai¹  Bin Yang¹  Tao Wang¹  Jia Dong²  Liqun Jiao³  Xiaoyan Yang⁴  Mengyue Li⁵  Adam A. Dmytriw⁶  Aman B. Patel⁷  Xinyu Tong⁸  Duanduan Chen⁸  Yuqian Mei⁹ 

[1] Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China;China International Neuroscience Institute (China-INI), Beijing, China;Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China;Interventional Neuroradiology Diagnosis and Treatment Center, Xuanwu Hospital, Capital Medical University, Beijing, China;Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China;Interventional Neuroradiology Diagnosis and Treatment Center, Xuanwu Hospital, Capital Medical University, Beijing, China;China International Neuroscience Institute (China-INI), Beijing, China;Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China;Interventional Neuroradiology Diagnosis and Treatment Center, Xuanwu Hospital, Capital Medical University, Beijing, China;Interventional Neuroradiology Diagnosis and Treatment Center, Xuanwu Hospital, Capital Medical University, Beijing, China;Neuroendovascular Program, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States;Neuroendovascular Program, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States;School of Life Science, Beijing Institute of Technology, Beijing, China;School of Life Science, Beijing Institute of Technology, Beijing, China;School of Medical Imaging, North Sichuan Medical College, Nanchong, China;

关键词: basilar artery fenestration;    ischemic stroke;    hemodynamic;    wall shear stress;    computational fluid dynamics;   

DOI  :  10.3389/fneur.2021.766174

 received in 2021-08-28, accepted in 2021-12-06,  发布年份 2022

来源: Frontiers

【 摘 要 】

Background: Basilar artery fenestration has been proposed as a contributor to ischemic stroke, as unique flow patterns induced by fenestration may be related to thrombus formation or insufficiency. This study aimed to evaluate the hemodynamics of basilar artery fenestration (BAF) using computational fluid dynamics (CFD).Methods: Patients with BAF and normal vertebrobasilar system were recruited and separately evaluated using CFD. Specific geometric vascular models were reconstructed based on 3D-rotational angiography (3D-RA). Patients were divided into the BAF group and control group (i.e., patients with the normal vertebrobasilar system). Hemodynamic and geometric variables were calculated and compared between groups using Student's t-test or Wilcoxon rank-sum test.Results: Overall, 24 patients were included, with 12 patients each in the BAF group and the control group. The BAF group had a significantly smaller basilar artery diameter than the control group (3.1 ± 0.51 vs. 3.76 ± 0.4, p = 0.002). Compared to the control group, the BAF group had higher values of maxOSI (median, 0.3 vs. 0.09, p = 0.028), TAWSSG (median, 983.42 vs. 565.39, p = 0.038) in the flow confluence, higher SAR-TAWSSG in bifurcation (median, 70.22 vs. 27.65, p = 0.002) and higher SAR-TAWSSG in basilar artery (median, 48.75 vs. 16.17, p < 0.001) of the vertebrobasilar artery.Conclusions: This pilot study suggested that hemodynamic differences between BAF and normal vertebrobasilar artery across multiple shear flow parameters. The disturbed flow in the BAF may increase the risk of thrombus formation, plaque instability, and subsequent ischemic cerebrovascular events. These should be confirmed by future studies.

【 授权许可】

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Copyright © 2022 Dong, Mei, Bai, Tong, Dmytriw, Yang, Wang, Patel, Yang, Li, Yang, Chen and Jiao.