Efficacy of a comprehensive strategy for the detection and treatment of hepatitis C infection in a population attending addiction centers

Frontiers in Public Health

Public Health

Inmaculada Ruiz-Cáceres¹  Laura Ruiz-Torres¹  Diana Corona-Mata¹  Antonio Rivero-Juárez²  Antonio Rivero²  Ignacio Pérez-Valero²  Ángela Camacho²  María Victoria Cabrera-Gisbert³  David Cáceres-Anillo³  María de Guía Castro-Granados⁴  Justa Redondo-Écija⁴  Bartolomé de la Fuente Darder⁴  Leticia Manchado-López⁴  María Lizaur-Barbudo⁴  Luciano Cobos⁴  Ana Aparicio-Aparicio⁴ 

[1] Infectious Diseases Department, Maimonides Institute of Biomedical Research of Córdoba (IMIBIC), Reina Sofía University Hospital of Córdoba, University of Córdoba, Córdoba, Spain;Infectious Diseases Department, Maimonides Institute of Biomedical Research of Córdoba (IMIBIC), Reina Sofía University Hospital of Córdoba, University of Córdoba, Córdoba, Spain;CIBERINFEC, ISCIII – CIBER of Infectious Diseases, Instituto de Salud Carlos III, Madrid, Spain;Renacer Home, Córdoba, Spain;Unidad de Drogas y Adicciones-CPD (UDA-CPD), Instituto Provincial Bienestar Social, Diputación Córdoba, Córdoba, Spain;

关键词: hepatitis C;    elimination;    microelimination;    drugs users;    addiction centers;    cirrhosis;   

DOI  :  10.3389/fpubh.2023.1092960

 received in 2022-11-08, accepted in 2023-01-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background and aimsThe burden hepatitis C infection in people with history or current drug use suppose a high risk of hepatic complications and transmission infectious disease. This population is poor linked to heath system and is difficult to achieve them and support treatment because they have high rates of lost follow-up. Our aim was to evaluate an intervention for the diagnosis and treatment of chronic hepatitis C and HIV in this population.MethodsSix-hundred and eighty-three people attended in Drugs and Addictions Centers (DAC) were asked to participate in health counseling and provide blood sample for test HCV, HIV, and syphilis from April 2019 to June 2020. Totally 556 subjects were surveyed and tested. All of them were assigned to a patient navigation program to improve health education and linking to the sanitary system. Hepatitis C infection patients were evaluated in an ampliated medical consult to evaluate hepatic stage with transient liver elastography and initiated Direct Acting Antivirals to achieve Sustained Viral Response.ResultsOf the 556 patients who agreed to participate in the study, 33 (5.9%) had active HCV infection. Of the 33 patients infected with HCV, three were lost to follow-up once the diagnosis of HCV infection was made. Twenty-eight patients (93.3%) completed treatment and 26 achieved Sustained Viral Response (78.8%). Of the 30 patients, seven (23.3%) had advanced fibrosis, and of these, four (16.6%) had liver cirrhosis. One of the cirrhotic patients had hepatic space-occupying lesions at the baseline evaluation and was diagnosed with hepatocarcinoma.ConclusionsOur study suggests that the implementation of strategies based on personalized intervention models can contribute to the control of HCV infection in DAC users.

【 授权许可】

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Copyright © 2023 Corona-Mata, Rivero-Juárez, Camacho, Ruiz-Torres, Ruiz-Cáceres, de la Fuente Darder, Cáceres-Anillo, de Guía Castro-Granados, Lizaur-Barbudo, Victoria Cabrera-Gisbert, Redondo-Écija, Aparicio-Aparicio, Manchado-López, Cobos, Pérez-Valero and Rivero.