PLGA-based drug delivery systems in treating bone tumors

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Fei Liu¹  Enduo Qiu² 

[1] Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China;null;

关键词: bone tumors;    PLGA;    delivery systems;    nanoparticles;    scaffolds;   

DOI  :  10.3389/fbioe.2023.1199343

 received in 2023-04-03, accepted in 2023-05-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

Bone tumor has become a common disease that endangers human health. Surgical resection of bone tumors not only causes biomechanical defects of bone but also destroys the continuity and integrity of bone and cannot completely remove the local tumor cells. The remaining tumor cells in the lesion bring a hidden danger of local recurrence. To improve the chemotherapeutic effect and effectively clear tumor cells, traditional systemic chemotherapy often requires higher doses, and high doses of chemotherapeutic drugs inevitably cause a series of systemic toxic side effects, often intolerable to patients. PLGA-based drug delivery systems, such as nano delivery systems and scaffold-based local delivery systems, can help eliminate tumors and promote bone regeneration and therefore have more significant potential for application in bone tumor treatment. In this review, we summarize the research progress of PLGA nano drug delivery systems and PLGA scaffold-based local delivery systems in bone tumor treatment applications, expecting to provide a theoretical basis for developing novel bone tumor treatment strategies.

【 授权许可】

Unknown   
Copyright © 2023 Qiu and Liu.