Effects of vitamin D supplementation on the regulation of blood lipid levels in prediabetic subjects: A meta-analysis

Frontiers in Nutrition

Nutrition

Bo Li¹  Yinpei Guo¹  Ling Wang¹  Nan Yao¹  Mengzi Sun¹  Wenyu Hu¹  Yixue Yang¹  Han Wang¹  Xiaotong Li¹  Shoumeng Yan² 

[1] Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China;School of Nursing, Jilin University, Changchun, Jilin, China;

关键词: vitamin D;    meta-analysis;    prediabetes;    cholesterol;    LDL cholesterol;    HDL cholesterol;    triglycerides;   

DOI  :  10.3389/fnut.2023.983515

 received in 2022-07-01, accepted in 2023-02-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

This meta-analysis aimed to systematically investigate whether vitamin D supplementation reduces blood lipid—total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and triglyceride (TG)—levels in prediabetic individuals. Pubmed, Web of Science, Cochrane Library, Embase, CNKI, and WANFANG databases were searched for studies published before 13 February 2022 (including 13 February 2022). Five articles were included. The results showed that vitamin D intervention led to a significant reduction in TG compared with control or placebo treatment (−0.42 [−0.59, −0.25], P < 0.001). Subgroup analyses showed that this effect was particularly significant among the studies that included obese subjects (−0.46 [−0.65, −0.28], P < 0.001), the studies that also included men (not only women) (−0.56 [−0.78, −0.34], P < 0.001), and the studies with intervention durations longer than 1 year (−0.46 [−0.65, −0.28], P < 0.001). Both relatively low doses of 2,857 IU/day (−0.65 [−0.92, −0.38], P < 0.001) and relatively high doses of 8,571 IU/day (−0.28 [−0.54, −0.02] P = 0.04) of vitamin D supplementation reduced TG levels, and the effect was observed both in Northern Europe (−0.65 [−0.92, −0.38], P < 0.001) and Asian (−0.25 [−0.48, −0.03], P = 0.03) country subgroups. No significant effects on TC, HDL-C, and LDL-C were shown. In conclusion, vitamin D supplementation might beneficially affect TG levels in individuals with prediabetes. Particularly longer durations of treatment, more than 1 year, with doses that correct vitamin deficiency/insufficiency, can have a beneficial effect. This meta-analysis was registered at www.crd.york.ac.uk/prospero (CRD42020160780).

【 授权许可】

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Copyright © 2023 Yang, Yan, Yao, Guo, Wang, Sun, Hu, Li, Wang and Li.