Imaging the cerebellum in post-traumatic stress and anxiety disorders: a mini-review

Frontiers in Systems Neuroscience

Neuroscience

Tomas Furmark¹  Patricia Gil-Paterna² 

[1] Department of Psychology, Uppsala University, Uppsala, Sweden;null;

关键词: cerebellum;    vermis;    anxiety;    stress;    PTSD;    human neuroimaging;    MRI;   

DOI  :  10.3389/fnsys.2023.1197350

 received in 2023-03-30, accepted in 2023-07-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Post-traumatic stress disorder (PTSD) and anxiety disorders are among the most prevalent psychiatric conditions worldwide sharing many clinical manifestations and, most likely, neural mechanisms as suggested by neuroimaging research. While the so-called fear circuitry and traditional limbic structures of the brain, particularly the amygdala, have been extensively studied in sufferers of these disorders, the cerebellum has been relatively underexplored. The aim of this paper was to present a mini-review of functional (task-activity or resting-state connectivity) and structural (gray matter volume) results on the cerebellum as reported in magnetic resonance imaging studies of patients with PTSD or anxiety disorders (49 selected studies in 1,494 patients). While mixed results were noted overall, e.g., regarding the direction of effects and anatomical localization, cerebellar structures like the vermis seem to be highly involved. Still, the neurofunctional and structural alterations reported for the cerebellum in excessive anxiety and trauma are complex, and in need of further evaluation.

【 授权许可】

Unknown   
Copyright © 2023 Gil-Paterna and Furmark.