Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years

Frontiers in Physiology

Physiology

Rashid Zaman¹  Neil David Clarke²  Ferman Konukman³  Yaodong Gu⁴  Monèm Jemni⁵  Michel Marina⁶  Lindsay Bottoms⁷  Roger Ramsbottom⁸  Norman Hoffman⁹  Shad James Groves⁹  Frederick Robert Carrick^1,10  Jagdeep Singh Matharoo^1,11 

[1] Centre for Mental Health Research in association with The University of Cambridge, Cambridge, United Kingdom;Department of Psychiatry, The University of Cambridge, Cambridge, United Kingdom;Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, United Kingdom;Department of Physical Education, College of Education, Qatar University, Doha, Qatar;Faculty of Physical Education, Ningbo University, Ningbo, Zhejiang, China;Faculty of Physical Education, Ningbo University, Ningbo, Zhejiang, China;The Carrick Institute of Neuroscience, Cape Canaveral, FL, United States;Centre for Mental Health Research in association with The University of Cambridge, Cambridge, United Kingdom;Institut Nacional d'Educació Física de Catalunya (INEFC), Sport Performance, Barcelona, Spain;School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Hertfordshire, United Kingdom;Sport and Health Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, United Kingdom;The Carrick Institute of Neuroscience, Cape Canaveral, FL, United States;The Carrick Institute of Neuroscience, Cape Canaveral, FL, United States;Centre for Mental Health Research in association with The University of Cambridge, Cambridge, United Kingdom;University of Central Florida College of Medicine, Orlando, FL, United states;MGH Institute of Health Professions, Boston, MA, United States;The University of Greenwich, London, United Kingdom;

关键词: BDNF expression;    exercise mode;    neuroplasticity;    depression treatment;    physical activity intervention;   

DOI  :  10.3389/fphys.2023.1102526

 received in 2022-11-19, accepted in 2023-01-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

The aim of this review was to explore the relevant neurobiology and the association between peripheral levels of brain-derived neurotrophic factor (BDNF) and acute and short to long-term exercise regimes, as well as its relation to depression and antidepressant treatment. A 20-year literature search was conducted. The screening process resulted in 100 manuscripts. Antidepressants as well as acute exercise, particularly high-intensity, elevates BDNF in healthy humans and clinical populations, as evidenced from aerobic and resistance-based studies. Although exercise is increasingly recognised in the management of depression, acute and short-term exercise studies have failed to establish a relationship between the severity of depression and changes in peripheral BDNF. The latter rapidly returns to baseline, possibly indicating a quick re-uptake by the brain, aiding its neuroplasticity functions. The timescale of administration needed for the antidepressants to stimulate biochemical changes is longer than similar increases with acute exercise.

【 授权许可】

Unknown   
Copyright © 2023 Jemni, Zaman, Carrick, Clarke, Marina, Bottoms, Matharoo, Ramsbottom, Hoffman, Groves, Gu and Konukman.