Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study

Frontiers in Psychology

Psychology

Anna Vilalta-Lacarra¹  Joan Vilalta-Franch²  Josep Garre-Olmo³  Domènec Serrano-Sarbosa⁴  Ruth Martí-Lluch⁵  Jaume Marrugat⁶ 

[1] Department of Medical Oncology, Clinica Universidad de Navarra, Pamplona, Spain;Girona Biomedical Research Institute (IDIBGI), Girona, Spain;Girona Biomedical Research Institute (IDIBGI), Girona, Spain;Department of Nursing, University of Girona, Girona, Spain;Girona Biomedical Research Institute (IDIBGI), Girona, Spain;Institut d'Assistencia Sanitaria, Girona, Spain;Department of Medical Sciences, University of Girona, Girona, Spain;Girona Biomedical Research Institute (IDIBGI), Girona, Spain;Vascular Health Research Group (ISV-Girona), Foundation University Institute for Primary Health Care Research Jordi Gol i Gurina, Girona, Spain;IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain;CIBERCV de Investigación en Enfermedades Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain;

关键词: depressive syndrome;    somatic symptoms;    mortality;    antidepressant drug;    cancer;   

DOI  :  10.3389/fpsyg.2023.1192462

 received in 2023-03-23, accepted in 2023-07-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveThis study aimed to assess the association of somatic depressive symptoms (SDS), cognitive/emotional depressive symptoms (C-EDS), and antidepressant treatment on mortality due to cancer and other causes in a community cohort.MethodsA community-based sample recruited in 1995, 2000, and 2005 aged between 35 and 75 years was examined in two waves and followed for a median of 6.7 years. SDS and C-EDS phenotypes were assessed using the Patient Health Questionnaire-9. Medication used by participants was collected. Deaths and their causes were registered during follow-up. Cox proportional hazard models stratified by sex were performed to determine the association between depressive phenotypes and mortality.ResultsThe cohort consisted of 5,646 individuals (53.9% women) with a mean age of 64 years (SD = 11.89). During the follow-up, 392 deaths were recorded, of which 27.8% were due to cancer. C-EDS phenotype was associated with an increased risk of cancer mortality in both men (HR = 2.23; 95% CI = 1.11–4.44) and women (HR = 3.69; 95% CI = 1.69–8.09), and SDS was significantly associated with non-cancer mortality in men (HR = 2.16; 95 CI % = 1.46–3.18). Selective serotonin reuptake inhibitors (SSRIs) were significantly associated with both cancer (HR = 2.78; 95% CI = 1.10–6.98) and non-cancer mortality (HR = 2.94; 95% CI = 1.76–4.90) only in the male population.ConclusionC-EDS phenotype was related to an increased risk of cancer mortality at 6 years. In addition, the use of SSRIs in the male population was associated with cancer and all-cause mortality.

【 授权许可】

Unknown   
Copyright © 2023 Vilalta-Lacarra, Vilalta-Franch, Serrano-Sarbosa, Martí-Lluch, Marrugat and Garre-Olmo.