Individual and combined associations of alanine aminotransferase and hemoglobin with metabolic syndrome in the elderly in Qingdao, China

Frontiers in Medicine

Medicine

Li Liu¹  Dongming Xing²  Enqiang Feng³  Yuhan Shao³  Zhugang Shao⁴ 

[1] Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China;Qingdao Cancer Institute, Qingdao, Shandong, China;Qingdao Municipal Center for Disease Control and Prevention, Qingdao, Shandong, China;Qingdao Institute of Preventive Medicine, Qingdao, Shandong, China;Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China;Qingdao Cancer Institute, Qingdao, Shandong, China;School of Life Sciences, Tsinghua University, Beijing, China;Qingdao Municipal Center for Disease Control and Prevention, Qingdao, Shandong, China;Qingdao Institute of Preventive Medicine, Qingdao, Shandong, China;Shandong Muhua Medical Technology Co., Ltd., Qingdao, Shandong, China;

关键词: alanine aminotransferase;    hemoglobin;    metabolic syndrome;    elderly;    combined association;   

DOI  :  10.3389/fmed.2023.1152747

 received in 2023-01-28, accepted in 2023-07-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background and aimsCombined associations of alanine aminotransferase (ALT) and hemoglobin (Hb) with metabolic syndrome (MetS) have not been assessed yet. The current study investigated the independent and combined relationships between ALT, Hb, and MetS in the elderly.MethodsThe 37,966 elderly participants aged 65 years and older were recruited from community centers in Qingdao, China. The sampled elderly population visited the health centers once a year where they were offered a free health checkup. Based on a combination of ALT and Hb levels categorized by tertile, participants were grouped into nine groups (Group 1–9). Logistic regression models were used to analyze the individual and combined associations of ALT and Hb with MetS.ResultsALT and Hb were both independently related to MetS in both genders. With the elevation of ALT or Hb levels, risks for MetS and its components increased. Compared to the reference group (the 1st tertiles of both ALT and Hb levels), respective odds ratio of combined ALT and Hb for MetS in Group 2–9 ranged from 1.32–3.38 and 1.14–2.31 in men and women after adjusting for age, sex, education, married status, current smoking, current drinking, physical activity, and diet habit.ConclusionALT and Hb were both independently related to MetS and its components. Combined ALT and Hb levels could increase risks of MetS and its components than an elevation in ALT or Hb alone.

【 授权许可】

Unknown   
Copyright © 2023 Liu, Shao, Feng, Shao and Xing.