Epigenetic associations with adolescent grey matter maturation and cognitive development

Frontiers in Genetics

Genetics

Yu-Ping Wang¹  Tony W. Wilson²  Julia M. Stephen³  Jingyu Liu⁴  Jiayu Chen⁴  Dawn Jensen⁵  Vince D. Calhoun⁶  Jessica A. Turner⁷ 

[1] Department of Biomedical Engineering, Tulane University, New Orleans, LA, United States;Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United States;The Mind Research Network, Albuquerque, NM, United States;Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, United States;Department of Computer Science, Georgia State University, Atlanta, GA, United States;Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, United States;Neuroscience Institute, Georgia State University, Atlanta, GA, United States;Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, United States;Neuroscience Institute, Georgia State University, Atlanta, GA, United States;Department of Computer Science, Georgia State University, Atlanta, GA, United States;The Mind Research Network, Albuquerque, NM, United States;Psychology Department and Neuroscience Institute, Georgia State University, Atlanta, GA, United States;Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, United States;Wexnar Medical Center, Department of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, United States;

关键词: adolescent development;    grey matter;    methylation;    neuroimaging epigenetics;    cognition;    sMRI;   

DOI  :  10.3389/fgene.2023.1222619

 received in 2023-05-17, accepted in 2023-06-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

Introduction: Adolescence, a critical phase of human neurodevelopment, is marked by a tremendous reorganization of the brain and accompanied by improved cognitive performance. This development is driven in part by gene expression, which in turn is partly regulated by DNA methylation (DNAm).Methods: We collected brain imaging, cognitive assessments, and DNAm in a longitudinal cohort of approximately 200 typically developing participants, aged 9–14. This data, from three time points roughly 1 year apart, was used to explore the relationships between seven cytosine–phosphate–guanine (CpG) sites in genes highly expressed in brain tissues (GRIN2D, GABRB3, KCNC1, SLC12A9, CHD5, STXBP5, and NFASC), seven networks of grey matter (GM) volume change, and scores from seven cognitive tests.Results: The demethylation of the CpGs as well as the rates of change in DNAm were significantly related to improvements in total, crystalized, and fluid cognition scores, executive function, episodic memory, and processing speed, as well as several networks of GM volume increases and decreases that highlight typical patterns of brain maturation.Discussion: Our study provides a first look at the DNAm of genes involved in myelination, excitatory and inhibitory receptors, and connectivity, how they are related to the large-scale changes occurring in the brain structure as well as cognition during adolescence.

【 授权许可】

Unknown   
Copyright © 2023 Jensen, Chen, Turner, Stephen, Wang, Wilson, Calhoun and Liu.