Non-canonical autophagy in aging and age-related diseases

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Anita V. Kumar¹  Joslyn Mills² 

[1] Molecular Biology, Cell Biology and Biochemistry Department, Brown University, Providence, RI, United States;Molecular Biology, Cell Biology and Biochemistry Department, Brown University, Providence, RI, United States;Wheaton College, Biology Department, Norton, MA, United States;

关键词: non-canonical autophagy;    aging;    neurodegenerative diseasaes;    secretory autophagy;    LAP (LC3 associated phagocytosis);    LANDO;   

DOI  :  10.3389/fcell.2023.1137870

 received in 2023-01-04, accepted in 2023-02-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

Autophagy, one of the arms of proteostasis, influences aging and age-related diseases. Recently, the discovery of additional roles of autophagy-related proteins in non-canonical degradation and secretion has revealed alternative fates of autophagic cargo. Some of these non-canonical pathways have been linked to neurodegenerative diseases and improving the understanding of this link is crucial for their potential targetability in aging and age-related diseases. This review discusses recent investigations of the involvement of non-canonical autophagy players and pathways in age-related diseases that are now beginning to be discovered. Unraveling these pathways and their relation to classical autophagy could unearth a fascinating new layer of proteostasis regulation during normal aging and in longevity.

【 授权许可】

Unknown   
Copyright © 2023 Kumar and Mills.