Emerging Role of Exosomal Long Non-coding RNAs in Spaceflight-Associated Risks in Astronauts

Frontiers in Genetics

Genetics

Arsen Arakelyan¹  Nathaniel Saffran²  Malik Bisserier²  Lahouaria Hadri²  Agnieszka Brojakowska²  David A. Goukassian²  Paul J. Mills³  Venkata Naga Srikanth Garikipati⁴  Aimy Sebastian⁵  Angela Clare Evans⁶  Matthew A. Coleman⁶  Kenneth Walsh⁷ 

[1] Bioinformatics Group, The Institute of Molecular Biology, The National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia;Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States;Center of Excellence for Research and Training in Integrative Health, University of California, San Diego, San Diego, CA, United States;Department of Emergency Medicine, Dorothy M. Davis Heart Lung and Research Institute, Ohio State University Wexner Medical Center, Columbus, OH, United States;Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States;Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States;Department of Radiation Oncology, University of California, Davis, Sacramento, CA, United States;School of Medicine, University of Virginia, Charlottesville, VA, United States;

关键词: exosomes;    lncRNA;    biomarkers;    astronauts;    spaceflight;   

DOI  :  10.3389/fgene.2021.812188

 received in 2021-11-09, accepted in 2021-12-21,  发布年份 2022

来源: Frontiers

【 摘 要 】

During spaceflight, astronauts are exposed to multiple unique environmental factors, particularly microgravity and ionizing radiation, that can cause a range of harmful health consequences. Over the past decades, increasing evidence demonstrates that the space environment can induce changes in gene expression and RNA processing. Long non-coding RNA (lncRNA) represent an emerging area of focus in molecular biology as they modulate chromatin structure and function, the transcription of neighboring genes, and affect RNA splicing, stability, and translation. They have been implicated in cancer development and associated with diverse cardiovascular conditions and associated risk factors. However, their role on astronauts’ health after spaceflight remains poorly understood. In this perspective article, we provide new insights into the potential role of exosomal lncRNA after spaceflight. We analyzed the transcriptional profile of exosomes isolated from peripheral blood plasma of three astronauts who flew on various Shuttle missions between 1998–2001 by RNA-sequencing. Computational analysis of the transcriptome of these exosomes identified 27 differentially expressed lncRNAs with a Log2 fold change, with molecular, cellular, and clinical implications.

【 授权许可】

Unknown   
Copyright © 2022 Bisserier, Saffran, Brojakowska, Sebastian, Evans, Coleman, Walsh, Mills, Garikipati, Arakelyan, Hadri and Goukassian.