Case report: Urbanized non-human primates as sentinels for human zoonotic diseases: a case of acute fatal toxoplasmosis in a free-ranging marmoset in coinfection with yellow fever virus

Frontiers in Public Health

Public Health

Cristiano B. Melo¹  Giane R. Paludo¹  Gabriela R. T. Costa²  Márcio B. Castro³  Tais M. Wilson³  Isabel L. Macêdo³  Davi E. R. Sousa³  Luiz Carlos Junior Alcantara⁴  Marta Giovanetti⁵  Ana Maria B. de Filippis⁶  Maria Angélica M. M. Mares-Guia⁶  Vagner S. Fonseca⁷  Pedro H. O. Passos⁸  Alessandro P. M. Romano⁸  Daniel G. Ramos⁸ 

[1] Graduate Program in Animal Science, University of Brasília, Brasilia, Brazil;Graduate Program in Animal Science, University of Brasília, Brasilia, Brazil;Environmental Health Surveillance Directorate of the Federal District, Brasilia, Brazil;Graduate Program in Animal Science, University of Brasília, Brasilia, Brazil;Veterinary Pathology Laboratory, University of Brasília, Brasília, Brazil;Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil;Laboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Instituto Osawldo Cruz, Fiocruz, Rio de Janeiro, Brazil;Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil;Sciences and Technologies for Sustainable Development and One Health, University of Campus Bio-Medico of Rome, Rome, Italy;Laboratório de Arbovírus e Vírus Hemorrágicos (LARBOH), Instituto Osawldo Cruz, Fiocruz, Rio de Janeiro, Brazil;Organização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, Brazil;Instituto Rene Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil;Technical Group of Arbovirus Surveillance, General Coordination of Communicable Diseases, Department of Communicable Disease Surveillance, Secretariat of Health Surveillance, Brazilian Ministry of Health, Brasilia, Brazil;

关键词: non-human primates;    toxoplasma gondii;    infectious diseases;    surveillance;    One Health;    zoonosis;   

DOI  :  10.3389/fpubh.2023.1236384

 received in 2023-06-07, accepted in 2023-07-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

Free-ranging non-human primates (NHP) can live in anthropized areas or urban environments in close contact with human populations. This condition can enable the emergence and transmission of high-impact zoonotic pathogens. For the first time, we detected a coinfection of the yellow fever (YF) virus with Toxoplasma gondii in a free-ranging NHP in a highly urbanized area of a metropolis in Brazil. Specifically, we observed this coinfection in a black-tufted marmoset found dead and taken for a necropsy by the local health surveillance service. After conducting an epidemiological investigation, characterizing the pathological features, and performing molecular assays, we confirmed that the marmoset developed an acute fatal infection caused by T. gondii in coinfection with a new YF virus South American-1 sub-lineage. As a result, we have raised concerns about the public health implications of these findings and discussed the importance of diagnosis and surveillance of zoonotic agents in urbanized NHPs. As competent hosts of zoonotic diseases such as YF and environmental sentinels for toxoplasmosis, NHPs play a crucial role in the One Health framework to predict and prevent the emergence of dangerous human pathogens.

【 授权许可】

Unknown   
Copyright © 2023 Sousa, Wilson, Macêdo, Romano, Ramos, Passos, Costa, Fonseca, Mares-Guia, Giovanetti, Alcantara, de Filippis, Paludo, Melo and Castro.