Uncovering new insights into the role of the ubiquitin ligase Smurf1 on the regulation of innate immune signaling and resistance to infection

Frontiers in Immunology

Immunology

Josiane Teixeira Andrade-Chaves¹  Juvana Moreira Andrade¹  Luiz Pedro Souza-Costa¹  Luis Henrique Franco¹  Vivian Vasconcelos Costa² 

[1] Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;

关键词: ubiquitin ligase;    ubiquitination;    Smurf1;    innate immunity;    infection;   

DOI  :  10.3389/fimmu.2023.1185741

 received in 2023-03-13, accepted in 2023-03-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

Innate immunity is the body’s first line of defense against infections. Innate immune cells express pattern recognition receptors in distinct cellular compartments that are responsible to detect either pathogens-associated molecules or cellular components derived from damaged cells, to trigger intracellular signaling pathways that lead to the activation of inflammatory responses. Inflammation is essential to coordinate immune cell recruitment, pathogen elimination and to keep normal tissue homeostasis. However, uncontrolled, misplaced or aberrant inflammatory responses could lead to tissue damage and drive chronic inflammatory diseases and autoimmunity. In this context, molecular mechanisms that tightly regulate the expression of molecules required for the signaling of innate immune receptors are crucial to prevent pathological immune responses. In this review, we discuss the ubiquitination process and its importance in the regulation of innate immune signaling and inflammation. Then, we summarize the roles of Smurf1, a protein that works on ubiquitination, on the regulation of innate immune signaling and antimicrobial mechanisms, emphasizing its substrates and highlighting its potential as a therapeutic target for infectious and inflammatory conditions.

【 授权许可】

Unknown   
Copyright © 2023 Souza-Costa, Andrade-Chaves, Andrade, Costa and Franco