Association between pediatric asthma and adult polycystic ovarian syndrome (PCOS): a cross-sectional analysis of the UAE healthy future Study (UAEHFS)

Frontiers in Endocrinology

Endocrinology

Marina Kazim¹  Naima Oumeziane¹  Habiba Alsafar²  Tom Loney³  Fatme Alanouti⁴  Abdulla AlNaeemi⁵  Michael Weitzman⁶  Juma Alkaabi⁷  Laila Abdel Wareth⁸  Mohammed Al-Houqani⁹  Ayesha S. Al Dhaheri^1,10  Eiman AlZaabi^1,11  Abdulla AlJunaibi^1,12  Scott Sherman^1,13  Omar El-Shahawy^1,13  Mohammed Hag-Ali^1,14  Mai Aljaber^1,15  Wael Almahmeed^1,16  Syed M. Shah^1,17  Fatma Al-Maskari^1,18  Abdishakur Abdulle^1,19  Fatima Mezhal^1,19  Andrea Leinberger-Jabari^1,19  Nirmin F. Juber^1,19  Youssef Idaghdour^1,19  Amar Ahmad^1,19  Raghib Ali^2,20 

[1] Abu Dhabi Blood Bank Services, SEHA, Abu Dhabi & Al-Ain, United Arab Emirates;Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates;Department of Genetics and Molecular Biology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates;Department of Biomedical Engineering, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates;College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates;College of Natural and Health Sciences, Zayed University, Abu Dhabi, United Arab Emirates;Department of Cardiology, Zayed Military Hospital, Abu Dhabi, United Arab Emirates;Department of Environmental Medicine, New York University of Medicine, New York, United States;Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates;Department of Laboratory Medicine, National Reference Laboratory, Abu Dhabi, United Arab Emirates;Department of Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates;Department of Nutrition and Health, College of Medicine and Health Sciences; United Arab Emirates University, Al-Ain, United Arab Emirates;Department of Pathology, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates;Department of Pediatrics, Zayed Military Hospital, Abu Dhabi, United Arab Emirates;Department of Population Health, New York University School of Medicine, New York, United States;Faculty of Health Sciences, Higher Colleges of Technology, Abu Dhabi, United Arab Emirates;Healthpoint Hospital, Abu Dhabi, United Arab Emirates;Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates;Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates;Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates;Zayed Center for Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates;Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates;Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates;Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom;

关键词: asthma;    pediatric asthma;    polycystic ovarian syndrome;    PCOS;    epidemiology;    risk factors;    public health;   

DOI  :  10.3389/fendo.2023.1022272

 received in 2022-08-18, accepted in 2023-05-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionAsthma and polycystic ovarian syndrome (PCOS) are linked in several possible ways. To date, there has been no study evaluating whether pediatric asthma is an independent risk factor for adult PCOS. Our study aimed to examine the association between pediatric asthma (diagnosed at 0-19 years) and adult PCOS (diagnosed at ≥20 years). We further assessed whether the aforementioned association differed in two phenotypes of adult PCOS which were diagnosed at 20-25 years (young adult PCOS), and at >25 years (older adult PCOS). We also evaluated whether the age of asthma diagnosis (0-10 vs 11-19 years) modified the association between pediatric asthma and adult PCOS.Material and methodsThis is a retrospective cross-sectional analysis using the United Arab Emirates Healthy Future Study (UAEHFS) collected from February 2016 to April 2022 involving 1334 Emirati females aged 18-49 years. We fitted a Poisson regression model to estimate the risk ratio (RR) and its 95% confidence interval (95% CI) to assess the association between pediatric asthma and adult PCOS adjusting for age, urbanicity at birth, and parental smoking at birth.ResultsAfter adjusting for confounding factors and comparing to non-asthmatic counterparts, we found that females with pediatric asthma had a statistically significant association with adult PCOS diagnosed at ≥20 years (RR=1.56, 95% CI: 1.02-2.41), with a stronger magnitude of the association found in the older adult PCOS phenotype diagnosed at >25 years (RR=2.06, 95% CI: 1.16-3.65). Further, we also found females reported thinner childhood body size had a two-fold to three-fold increased risk of adult PCOS diagnosed at ≥20 years in main analysis and stratified analyses by age of asthma and PCOS diagnoses (RR=2.06, 95% CI: 1.08-3.93 in main analysis; RR=2.74, 95% CI: 1.22-6.15 among those diagnosed with PCOS > 25 years; and RR=3.50, 95% CI: 1.38-8.43 among those diagnosed with asthma at 11-19 years).ConclusionsPediatric asthma was found to be an independent risk factor for adult PCOS. More targeted surveillance for those at risk of adult PCOS among pediatric asthmatics may prevent or delay PCOS in this at-risk group. Future studies with robust longitudinal designs aimed to elucidate the exact mechanism between pediatric asthma and PCOS are warranted.

【 授权许可】

Unknown   
Copyright © 2023 Juber, Abdulle, AlJunaibi, AlNaeemi, Ahmad, Leinberger-Jabari, Al Dhaheri, AlZaabi, Mezhal, Al-Maskari, Alanouti, Alsafar, Alkaabi, Wareth, Aljaber, Kazim, Weitzman, Al-Houqani, Hag-Ali, Oumeziane, El-Shahawy, Sherman, Shah, Loney, Almahmeed, Idaghdour and Ali