Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Ming-Shan Chen¹  Muhammad Munir²  Yi-Ying Wu³  Hung-Jen Liu⁴  Te-Kai Sun⁵ 

[1] Department of Anesthesiology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan;Department of Biomedical and Life Sciences, Lancaster University, Lancashire, United Kingdom;Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan;The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan;Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan;The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan;Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan;Ph.D Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan;Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan;Tsairder Boitechnology Co. Ltd., Taichung, Taiwan;

关键词: oncolytic viruses;    virotherapy;    immunotherapy;    apoptosis;    immune system;    autophagy;    immunogenic cell death;   

DOI  :  10.3389/fcimb.2023.1142172

 received in 2023-01-11, accepted in 2023-02-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis virus (VSV), parvovirus, mammalian reovirus (MRV), human adenovirus, Newcastle disease virus (NDV), herpes simplex virus (HSV), avian reovirus (ARV), Orf virus (ORFV), inactivated Sendai virus (ISV), enterovirus, and coxsackievirus offer unique opportunities in immunotherapy through diverse and dynamic pathways. This mini-review focuses on the mechanisms of OVs-mediated virotherapy and their effects on immunogenic cell death (ICD), apoptosis, autophagy and regulation of the immune system.

【 授权许可】

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Copyright © 2023 Wu, Sun, Chen, Munir and Liu