Frontiers in Cellular and Infection Microbiology | |
Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response | |
Cellular and Infection Microbiology | |
Ming-Shan Chen1  Muhammad Munir2  Yi-Ying Wu3  Hung-Jen Liu4  Te-Kai Sun5  | |
[1] Department of Anesthesiology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan;Department of Biomedical and Life Sciences, Lancaster University, Lancashire, United Kingdom;Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan;The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan;Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan;The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan;Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan;Ph.D Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan;Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan;Tsairder Boitechnology Co. Ltd., Taichung, Taiwan; | |
关键词: oncolytic viruses; virotherapy; immunotherapy; apoptosis; immune system; autophagy; immunogenic cell death; | |
DOI : 10.3389/fcimb.2023.1142172 | |
received in 2023-01-11, accepted in 2023-02-28, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis virus (VSV), parvovirus, mammalian reovirus (MRV), human adenovirus, Newcastle disease virus (NDV), herpes simplex virus (HSV), avian reovirus (ARV), Orf virus (ORFV), inactivated Sendai virus (ISV), enterovirus, and coxsackievirus offer unique opportunities in immunotherapy through diverse and dynamic pathways. This mini-review focuses on the mechanisms of OVs-mediated virotherapy and their effects on immunogenic cell death (ICD), apoptosis, autophagy and regulation of the immune system.
【 授权许可】
Unknown
Copyright © 2023 Wu, Sun, Chen, Munir and Liu
【 预 览 】
Files | Size | Format | View |
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RO202310102860301ZK.pdf | 677KB | download |