Sarcopenia index based on serum creatinine and cystatin C is associated with mortality in middle-aged and older adults in Chinese: A retrospective cohort study from the China Health and Retirement Longitudinal Study

Frontiers in Public Health

Public Health

Yingmu Tong¹  Yang Wu²  Yunxiang Long²  Jie Ren²  Hai Wang²  Xing Zhang²  Qinglin Li²  Chang Liu³ 

[1] Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;Department of Surgical ICU, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;

关键词: sarcopenia;    middle-aged;    all-cause mortality;    older adults;    CHARLS;   

DOI  :  10.3389/fpubh.2023.1122922

 received in 2022-12-14, accepted in 2023-02-08,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe sarcopenia index (SI, serum creatinine/serum cystatin C × 100) is recommended for predicting sarcopenia. There were several studies showing that lower SI is associated with poorer outcomes in the older adults. However, the cohorts studied in these researches were mainly patients hospitalized. The aim of this study was to evaluate the correlation between SI and all-cause mortality among middle-aged and older adults from the China Health and Retirement Longitudinal Study (CHARLS).Materials and methodsA total of 8,328 participants meeting the criteria were enrolled in this study from CHARLS between 2011 and 2012. SI was calculated as [serum creatinine (mg/dL)/cystatin C (mg/L)] × 100. Mann-Whitney U-test and Fisher's exact test were used to assess balance in baseline characteristics. Kaplan-Meier, log-rang analysis, univariate and multivariate Cox hazard ratio regression models were used to compare the mortality between different SI levels. The dose relationship between sarcopenia index and all-cause mortality was further assessed by the cubic spline functions and smooth curve fitting.ResultsAfter adjustment for potential covariates, we found SI was significantly correlated with all-cause mortality [Hazard Ratio (HR) = 0.983, 95% confidence interval (CI) 0.977–0.988, P < 0.001]. Similarly, as SI was used as a categorical variable according to quartiles, higher SI was associated with lower mortality [Hazard Ratio (HR) = 0.44, 95% CI 0.34–0.57, P < 0.001] after adjustment for confounders.ConclusionsLower sarcopenia index was associated with higher mortality among middle-aged and older adults in China.

【 授权许可】

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Copyright © 2023 Wu, Wang, Tong, Zhang, Long, Li, Ren and Liu.