Frontiers in Cell and Developmental Biology | |
JAZF1: A metabolic actor subunit of the NuA4/TIP60 chromatin modifying complex | |
Cell and Developmental Biology | |
Amel Mameri1  Jacques Côté2  | |
[1] St. Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Oncology Division of CHU de Québec-Université Laval Research Center, Quebec City, QC, Canada;null; | |
关键词: epigenetics; acetylation; acetyl-CoA; gene expression; lipogenesis; lipolysis; | |
DOI : 10.3389/fcell.2023.1134268 | |
received in 2022-12-30, accepted in 2023-03-29, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
The multisubunit NuA4/TIP60 complex is a lysine acetyltransferase, chromatin modifying factor and gene co-activator involved in diverse biological processes. The past decade has seen a growing appreciation for its role as a metabolic effector and modulator. However, molecular insights are scarce and often contradictory, underscoring the need for further mechanistic investigation. A particularly exciting route emerged with the recent identification of a novel subunit, JAZF1, which has been extensively linked to metabolic homeostasis. This review summarizes the major findings implicating NuA4/TIP60 in metabolism, especially in light of JAZF1 as part of the complex.
【 授权许可】
Unknown
Copyright © 2023 Mameri and Côté.
【 预 览 】
Files | Size | Format | View |
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RO202310102752498ZK.pdf | 1357KB | download |