JAZF1: A metabolic actor subunit of the NuA4/TIP60 chromatin modifying complex

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Amel Mameri¹  Jacques Côté² 

[1] St. Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Oncology Division of CHU de Québec-Université Laval Research Center, Quebec City, QC, Canada;null;

关键词: epigenetics;    acetylation;    acetyl-CoA;    gene expression;    lipogenesis;    lipolysis;   

DOI  :  10.3389/fcell.2023.1134268

 received in 2022-12-30, accepted in 2023-03-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

The multisubunit NuA4/TIP60 complex is a lysine acetyltransferase, chromatin modifying factor and gene co-activator involved in diverse biological processes. The past decade has seen a growing appreciation for its role as a metabolic effector and modulator. However, molecular insights are scarce and often contradictory, underscoring the need for further mechanistic investigation. A particularly exciting route emerged with the recent identification of a novel subunit, JAZF1, which has been extensively linked to metabolic homeostasis. This review summarizes the major findings implicating NuA4/TIP60 in metabolism, especially in light of JAZF1 as part of the complex.

【 授权许可】

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