Gastric precancerous lesions:occurrence, development factors, and treatment

Frontiers in Oncology

Oncology

Zengzheng Li¹  Guiyun Mo²  Yinghui Peng³  Dongcai Wang³  Yue Cao³ 

[1] Department of Hematology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, China;Yunnan Province Clinical Center for Hematologic Disease, The First People’s Hospital of Yunnan Province, Kunming, China;Yunnan Blood Disease Hospital, The First People’s Hospital of Yunnan Province, Kunming, China;National Key Clinical Specialty of Hematology, The First People’s Hospital of Yunnan Province, Kunming, China;Yunnan Province Clinical Research Center for Hematologic Disease, The First People’s Hospital of Yunnan Province, Kunming, China;Emergency Teaching and Research Department of the First Clinical School of Yunnan University of Traditional Chinese Medicine, Kunming, China;Emergency of Department, Yunnan Provincial Hospital of Traditional Chinese Medicine, The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, China;

关键词: gastric precancerous lesions;    gastric cancer;    traditional Chinese medicine;    H.pylori;    treatment;   

DOI  :  10.3389/fonc.2023.1226652

 received in 2023-05-22, accepted in 2023-08-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Patients with gastric precancerous lesions (GPL) have a higher risk of gastric cancer (GC). However, the transformation of GPL into GC is an ongoing process that takes several years. At present, several factors including H.Pylori (Hp), flora imbalance, inflammatory factors, genetic variations, Claudin-4, gastric stem cells, solute carrier family member 26 (SLC26A9), bile reflux, exosomes, and miR-30a plays a considerable role in the transformation of GPL into GC. Moreover, timely intervention in the event of GPL can reduce the risk of GC. In clinical practice, GPL is mainly treated with endoscopy, acid suppression therapy, Hp eradication, a cyclooxygenase-2 inhibitor, aspirin, and diet. Currently, the use of traditional Chinese medicine (TCM) or combination with western medication to remove Hp and the use of TCM to treat GPL are common in Asia, particularly China, and have also demonstrated excellent clinical efficacy. This review thoroughly discussed the combining of TCM and Western therapy for the treatment of precancerous lesions as conditions allow. Consequently, this review also focuses on the causes of the development and progression of GPL, as well as its current treatment. This may help us understand GPL and related treatment.

【 授权许可】

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Copyright © 2023 Cao, Wang, Mo, Peng and Li