C-reactive protein to lymphocyte ratio is a significant predictive factor for poor short-term clinical outcomes of SARS-CoV-2 BA.2.2 patients

Frontiers in Public Health

Public Health

Huazheng Liang¹  Zhangwei Yang²  Yinyan Wu³  Yudi Han³  Jingjing Xiao³  Benjie Xiao³  Yong Bi⁴ 

[1] Clinical Research Center for Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China;Monash Suzhou Research Institute, Suzhou, Jiangsu Province, China;Department of Information, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China;Department of Neurology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China;Shanghai University of Medicine & Health Sciences Affiliated Zhoupu hospital, Shanghai, China;Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China;

关键词: SARS-CoV-2 BA.2.2;    C-reactive protein to lymphocyte ratio;    cut-off value;    clinical outcomes;    multivariate logistic regression;   

DOI  :  10.3389/fpubh.2023.1168375

 received in 2023-02-17, accepted in 2023-03-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveThe aim of the present study is to assess the utility of C-reactive protein to Lymphocyte Ratio (CLR) in predicting short-term clinical outcomes of patients infected by SARS-CoV-2 BA.2.2.MethodsThis retrospective study was performed on 1,219 patients with laboratory-confirmed SARS-CoV-2 BA.2.2 to determine the association of CLR with short-term clinical outcomes. Independent Chi square test, Rank sum test, and binary logistic regression analysis were performed to calculate mean differences and adjusted odds ratios (aORs) with their 95% CI, respectively.ResultsOver 8% of patients admitted due to SARS-CoV-2 BA.2.2. were critically ill. The best cut-off value of CLR was 21.25 in the ROC with a sensitivity of 72.3% and a specificity of 86%. After adjusting age, gender, and comorbidities, binary logistic regression analysis showed that elevated CLR was an independent risk factor for poor short-term clinical outcomes of COVID-19 patients.ConclusionC-reactive protein to Lymphocyte Ratio is a significant predictive factor for poor short-term clinical outcomes of SARS-CoV-2 BA.2.2 inflicted patients.

【 授权许可】

Unknown   
Copyright © 2023 Xiao, Wu, Liang, Xiao, Han, Yang and Bi.