Gut microbiota and chronic obstructive pulmonary disease: a Mendelian randomization study

Frontiers in Microbiology

Microbiology

Yi Wei¹  Chao Liu²  Xuechao Lu³ 

[1] Department of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China;Department of Medical Imaging, Qingdao Traditional Chinese Medicine Hospital (Qingdao Hiser Hospital), Qingdao, China;Department of Respiratory and Critical Care Medicine, Qingdao Traditional Chinese Medicine Hospital (Qingdao Hiser Hospital), Qingdao, China;

关键词: gut microbiota;    chronic obstructive pulmonary disease;    Mendelian randomization;    causal association;    genome-wide association study;   

DOI  :  10.3389/fmicb.2023.1196751

 received in 2023-03-30, accepted in 2023-05-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundA growing number of studies implies a strong association between gut microbiota and chronic obstructive pulmonary disease (COPD). However, the causal impact between gut microbiota and COPD remains unclear. As a result, we used a two-sample Mendelian randomization (MR) method to investigate the connection between gut microbiota and COPD in this study.MethodsThe largest available genome-wide association study (GWAS) of gut microbiota was obtained from the MiBioGen consortium. Summary-level dataset for COPD were obtained from the FinnGen consortium. The main analysis method for determining the causal link between gut microbiota and COPD was inverse variance weighted (IVW). Subsequently, pleiotropy and heterogeneity tests were performed to determine the reliability of the results.ResultsIVW method identified 9 bacterial taxa nominally associated with the risk of COPD. Class Actinobacteria (p = 0.020), genus Allisonella (p = 0.024), genus Coprococcus2 (p = 0.002) and genus Oscillospira (p = 0.018) were protective against COPD. In addition, order Desulfovibrionales (p = 0.011), family Desulfovibrionaceae (p = 0.039), family Peptococcaceae (p = 0.020), family Victivallaceae (p = 0.012) and genus Marvinbryantia (p = 0.017) were associated with a higher risk of COPD. No pleiotropy or heterogeneity were found.ConclusionAccording to the findings of this MR analysis, a causal relationship exists between certain gut microbiota and COPD. New insights into the mechanisms of COPD mediated by gut microbiota are provided.

【 授权许可】

Unknown   
Copyright © 2023 Wei, Lu and Liu.