Increased posterior cingulate cortex blood flow in cancer-related fatigue

Frontiers in Neurology

Neurology

Patrick Z. Liu¹  Rupal Bhavsar²  David Raizen³  Hengyi Rao⁴  Timothy P. Kegelman⁵  Neha Vapiwala⁶  Brendan T. Keenan⁷  Hann-Hsiang Chao⁸ 

[1] Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, PA, United States;Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, PA, United States;Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, PA, United States;Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Shanghai Key Laboratory of Brain-Machine Intelligence for Information Behavior, Center for Magnetic Resonance Imaging Research, Shanghai International Studies University, Shanghai, China;Department of Radiation Oncology, ChristianaCare, Newark, DE, United States;Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, PA, United States;Radiation Oncology Service, Richmond VA Medical Center, Richmond, VA, United States;Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, United States;

关键词: fatigue;    cancer;    default mode network;    functional MRI;    posterior cingulate cortex;    sleep;    cerebral blood flow;    arterial spin labeling;   

DOI  :  10.3389/fneur.2023.1135462

 received in 2022-12-31, accepted in 2023-06-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

Fatigue is a common symptom associated with cancer treatments. Brain mechanisms underlying cancer-related fatigue (CRF) and its progression following therapy are poorly understood. Previous studies have suggested a role of the default mode network (DMN) in fatigue. In this study we used arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI) and compared resting cerebral blood flow (CBF) differences in the posterior cingulate cortex (PCC), a core hub of the DMN, between 16 patients treated with radiation therapy (RAT) for prostate (9 males) or breast (7 females) cancer and 18 healthy controls (HC). Resting CBF in patients was also measured immediately after the performance of a fatiguing 20-min psychomotor vigilance task (PVT). Twelve of 16 cancer patients were further followed between 3 and 7 months after completion of the RAT (post-RAT). Patients reported elevated fatigue on RAT in comparison to post-RAT, but no change in sleepiness, suggesting that the underlying neural mechanisms of CRF progression are distinct from those regulating sleep drive progression. Compared to HC, patients showed significantly increased resting CBF in the PCC and the elevated PCC CBF persisted during the follow up visit. Post-PVT, but not pre-PVT, resting CBF changes in the PCC correlated with fatigue changes after therapy in patients with CRF, suggesting that PCC CBF following a fatiguing cognitive task may be a biomarker for CRF recovery.

【 授权许可】

Unknown   
Copyright © 2023 Raizen, Bhavsar, Keenan, Liu, Kegelman, Chao, Vapiwala and Rao.