Cardiovascular outcomes of cancer patients in rural Australia

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Doan T. M. Ngo¹  Vanessa Clark²  Rhonda Walker³  Thomas Warner³  Amandeep Kaur³  Aaron L. Sverdlov⁴  Maria Aslam⁵  Trent D. Williams⁶ 

[1] Hunter Medical Research Institute, Newcastle, NSW, Australia;Newcastle Centre of Excellence in Cardio-Oncology, New Lambton Heights, NSW, Australia;School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia;Hunter Medical Research Institute, Newcastle, NSW, Australia;School of Nursing and Midwifery, College of Health Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia;Hunter Medical Research Institute Asthma and Breathing Research Program, Newcastle, NSW, Australia;Hunter New England Local Health District, New Lambton, NSW, Australia;Hunter New England Local Health District, New Lambton, NSW, Australia;Hunter Medical Research Institute, Newcastle, NSW, Australia;Newcastle Centre of Excellence in Cardio-Oncology, New Lambton Heights, NSW, Australia;School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia;Hunter New England Local Health District, New Lambton, NSW, Australia;Hunter Medical Research Institute, Newcastle, NSW, Australia;School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia;Hunter New England Local Health District, New Lambton, NSW, Australia;Hunter Medical Research Institute, Newcastle, NSW, Australia;School of Nursing and Midwifery, College of Health Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia;Nursing and Midwifery Centre: Hunter New England Local Health District, New Lambton, NSW, Australia;Newcastle Centre of Excellence in Cardio-Oncology, New Lambton Heights, NSW, Australia;

关键词: cardio-oncolody;    cardiovasccular risk factors;    cancer;    rural;    prevention;    acute coronaiy syndrome;    heart failiure;    atrial fibillation;   

DOI  :  10.3389/fcvm.2023.1144240

 received in 2023-01-14, accepted in 2023-03-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundCancer and heart disease are the two most common health conditions in the world, associated with high morbidity and mortality, with even worse outcomes in regional areas. Cardiovascular disease is the leading cause of death in cancer survivors. We aimed to evaluate the cardiovascular outcomes of patients receiving cancer treatment (CT) in a regional hospital.MethodsThis was an observational retrospective cohort study in a single rural hospital over a ten-year period (17th February 2010 to 19th March 2019). Outcomes of all patients receiving CT during this period were compared to those who were admitted to the hospital without a cancer diagnosis.Results268 patients received CT during the study period. High rates of cardiovascular risk factors: hypertension (52.2%), smoking (54.9%), and dyslipidaemia (38.4%) were observed in the CT group. Patients who had CT were more likely to be readmitted with ACS (5.9% vs. 2.8% p = 0.005) and AF (8.2% vs. 4.5% p = 0.006) when compared to the general admission cohort. There was a statistically significant difference observed for all cause cardiac readmission, with a higher rate observed in the CT group (17.1% vs. 13.2% p = 0.042). Patients undergoing CT had a higher rate of mortality (49.5% vs. 10.2%, p ≤ 0.001) and shorter time (days) from first admission to death (401.06 vs. 994.91, p ≤ 0.001) when compared to the general admission cohort, acknowledging this reduction in survival may be driven at least in part by the cancer itself.ConclusionThere is an increased incidence of adverse cardiovascular outcomes, including higher readmission rate, higher mortality rate and shorter survival in people undergoing cancer treatment in rural environments. Rural cancer patients demonstrated a high burden of cardiovascular risk factors.

【 授权许可】

Unknown   
© 2023 Williams, Kaur, Warner, Aslam, Clark, Walker, Ngo and Sverdlov.