Case report: Post-COVID new-onset neurocognitive decline with bilateral mesial-temporal hypometabolism in two previously healthy sisters

Frontiers in Pediatrics

Pediatrics

Valentina Arcangeli¹  Daniela Pia Rosaria Chieffo²  Ilaria Lazzareschi³  Rosa Morello³  Giuseppe Zampino³  Danilo Buonsenso⁴  Fabrizio Cocciolillo⁵  Alessandro Giordano⁶  Piero Valentini⁷ 

[1] Clinical Psychology Unit, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy;Clinical Psychology Unit, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy;Department of Woman, Children and Public Health, Catholic University of Sacred Heart, Rome, Italy;Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;Centro di Salute Globale, Università Cattolica del Sacro Cuore, Roma, Italy;Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Medicina Nucleare, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy;Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Medicina Nucleare, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy;Sezione di Medicina Nucleare, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy;Sezione di Medicina Nucleare, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy;

关键词: COVID-19;    long COVID;    children;    post-COVID condition;    SARS-CoV-2;   

DOI  :  10.3389/fped.2023.1165072

 received in 2023-02-13, accepted in 2023-04-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundLong coronavirus disease (COVID) is increasingly recognized in adults and children; however, it is still poorly characterized from a clinical and diagnostic perspective, particularly in the younger populations.Case presentationWe described the story of two sisters—with high social and academic performance before their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection—who reported severe neurocognitive problems, initially classified as psychologic pandemic distress and eventually found to have significant brain hypometabolism.ConclusionsWe provided a detailed clinical presentation of neurocognitive symptoms in two sisters with long COVID associated with brain hypometabolism documented in both sisters. We believe that the evidence of objective findings in these children further supports the hypothesis that organic events cause persisting symptoms in a cohort of children after SARS-CoV-2 infection. Such findings highlight the importance of discovering diagnostics and therapeutics.

【 授权许可】

Unknown   
© 2023 Cocciolillo, Chieffo, Giordano, Arcangeli, Lazzareschi, Morello, Zampino, Valentini and Buonsenso.