Case report: Regression of Glioblastoma after flavivirus infection

Frontiers in Medicine

Medicine

Felipe Andreiuolo¹  Paulo Niemeyer¹  Leila Chimelli¹  Luiz Gustavo Dubois²  Nina Ventura³  André Guasti⁴  Richard Araújo Maia⁵  Liane de Jesus Ribeiro⁵  Luiza Mendonça Higa⁶  Orlando da Costa Ferreira Júnior⁶  Amilcar Tanuri⁶  Patricia P. Garcez⁷  Gabriella Pinheiro A. de Freitas⁷  Vivaldo Moura-Neto⁸  Waleska Dias Schwarcz⁹  Elena Cristina Caride⁹  Adriana de Souza Azevedo⁹  Sheila Maria Barbosa de Lima⁹ 

[1] Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil;Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil;Campus UFRJ Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil;Departamento de Radiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil;Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil;Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;Núcleo de Enfrentamentos e Estudos de Doenças Infecciosas Emergentes e Reemergentes (NEEDIER), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil;Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz, Rio de Janeiro, Brazil;

关键词: glioblastoma;    flavivirus;    oncolytic virus;    ZIKV;    DENV;    immunovirotherapy;   

DOI  :  10.3389/fmed.2023.1192070

 received in 2023-03-22, accepted in 2023-05-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

Glioblastoma is the most frequent and aggressive primary brain cancer. In preclinical studies, Zika virus, a flavivirus that triggers the death of glioblastoma stem-like cells. However, the flavivirus oncolytic activity has not been demonstrated in human patients. Here we report a glioblastoma patient who received the standard of care therapy, including surgical resection, radiotherapy and temozolomide. However, shortly after the tumor mass resection, the patient was clinically diagnosed with a typical arbovirus-like infection, during a Zika virus outbreak in Brazil. Following the infection resolution, the glioblastoma regressed, and no recurrence was observed. This clinical response continues 6 years after the glioblastoma initial diagnosis.

【 授权许可】

Unknown   
Copyright © 2023 Garcez, Guasti, Ventura, Higa, Andreiuolo, de Freitas, Ribeiro, Maia, de Lima, de Souza Azevedo, Schwarcz, Caride, Chimelli, Dubois, Ferreira Júnior, Tanuri, Moura-Neto and Niemeyer.