The prevalence of osteoporosis in China, a community based cohort study of osteoporosis

Frontiers in Public Health

Public Health

Xin-chao Lin¹  Xing-wen Xie²  Zhang-yu Liao³  Bo-lai Chen⁴  Xiang-yang Leng⁵  Bing Shu⁶  Chen-guang Li⁷  Xue-jun Cui⁷  Jing Wang⁸  Qi Shi⁹  Yong-jun Wang⁹  Yan Zhang^1,10  Sheng Lu^1,10  De-zhi Tang^1,10  Bao-lin Li^1,11  Xiao-bing Jiang^1,12  Qing Zhang^1,13  Xu Wei^1,14  Li-juan Jiang^1,15 

[1] Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China;Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China;Ganzhou Nankang District Traditional Chinese Medicine Hospital, Ganzhou, China;Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China;Hospital Affiliated to Changchun University of Traditional Chinese Medicine, Changchun, China;Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China;Shanghai University of Traditional Chinese Medicine, Shanghai, China;Spine Institute, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China;Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China;Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China;Shanghai Geriatric Institute of Chinese Medicine, Shanghai, China;Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China;Shanghai University of Traditional Chinese Medicine, Shanghai, China;Spine Institute, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China;Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China;Spine Institute, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China;Shenzhen Pingle Orthopaedic Hospital, Shenzhen, China;The First Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine, Guangzhou, China;The First People's Hospital of Nankang District, Ganzhou, China;Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China;Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China;

关键词: prevalence;    osteoporosis;    China;    epidemiology;    risk factors;    cross-sectional study;   

DOI  :  10.3389/fpubh.2023.1084005

 received in 2022-10-29, accepted in 2023-01-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundOsteoporosis has already been a growing health concern worldwide. The influence of living area, lifestyle, socioeconomic, and medical conditions on the occurrence of osteoporosis in the middle-aged and elderly people in China has not been fully addressed.MethodsThe study was a multicenter cross-sectional study on the middle-aged and elderly permanent residents, which gathered information of 22,081 residents from June 2015 to August 2021 in seven representative regions of China. The bone mineral density of lumbar vertebrae and hip were determined using the dual-energy X-ray absorptiometry densitometer instruments. Serum levels of bone metabolism markers were also measured. Information about education, smoking, and chronic diseases were also collected through face-to-face interviews. Age-standardized prevalence and 95% confidence intervals (CIs) of osteopenia and osteoporosis by various criteria were estimated by subgroups and overall based on the data of China 2010 census. The relationships between the osteoporosis or osteopenia and sociodemographic variables or other factors were examined using univariate linear models and multivariable multinomial logit analyses.ResultsAfter screening, 19,848 participants (90%) were enrolled for the final analysis. The age-standardized prevalence of osteoporosis was estimated to be 33.49%(95%CI, 32.80–34.18%) in the middle-aged and elderly Chinese permanent residents, for men and women was 20.73% (95% CI, 19.58–21.87%) and 38.05% (95% CI, 37.22–38.89%), respectively. The serum concentrations of bone metabolic markers, and calcium and phosphorus metabolism were influenced by age, body mass index (BMI), gender, education level, regions, and bone mass status. Women, aged 60 or above, BMI lower than 18.5 kg/m2, low education level including middle school, primary school and no formal education as well as current regular smoking, a history of fracture were all significantly associated with a higher risk of osteoporosis and osteopenia in the middle-aged and elderly people.ConclusionsThis study revealed dramatic regional differences in osteoporosis prevalence in China, and female, aged 60 or older, low BMI, low education level, current regular smoking, and a history of fracture were associated with a high risk of osteoporosis. More prevention and treatment resources should be invested into particular population exposed to these risk factors.

【 授权许可】

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Copyright © 2023 Wang, Shu, Tang, Li, Xie, Jiang, Jiang, Chen, Lin, Wei, Leng, Liao, Li, Zhang, Cui, Zhang, Lu, Shi and Wang.