Hormone replacement therapy alone or in combination with tamoxifen in women with thin endometrium undergoing frozen-thawed embryo transfer: A retrospective study

Frontiers in Endocrinology

Endocrinology

Feifei Lu¹  Yifan Li¹  Qingqing Shi¹  Chenyang Huang¹  Jie Mei¹  Jingyu Liu¹  Na Kong¹  Yanxin Sun¹  Guijun Yan¹  Xiaoyue Shen¹  Haixiang Sun¹ 

[1] Center for Reproductive Medicine and Obstetrics and Gynecology, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing, China;Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China;Center for Molecular Reproductive Medicine, Nanjing University, Nanjing, China;

关键词: thin endometrium;    tamoxifen;    hormone replacement;    pregnancy outcomes;    frozen-thawed embryo transfer;   

DOI  :  10.3389/fendo.2023.1102706

 received in 2022-11-19, accepted in 2023-02-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Research questionTo investigate the effects of two protocols (hormone replacement therapy (HRT) alone or in combination with tamoxifen) on the endometrium and pregnancy outcome of patients with thin endometrium in frozen-thawed embryo transfer (FET) cycles.DesignA total of 465 infertile patients with thin endometrium who underwent FET between January 2020 to June 2021 at the Drum Tower Hospital affiliated with Nanjing University Medical School were retrospectively analyzed. A total of 187 patients were given tamoxifen in addition to HRT (TMXF-HRT group), whereas 278 patients were given only HRT (HRT group). Clinical data were compared between the two groups, including general characteristics, endometrial thickness, and clinical pregnancy outcomes.ResultsThere were no significant differences in baseline characteristics of all enrolled patients between two groups. Serum progesterone (P) was higher in HRT group than in the TMXF-HRT group (0.28 ± 0.53 ng/mL vs. 0.15 ± 0.25 ng/mL, P = 0.002). There was a significant increase in endometrial thickness in the TMXF-HRT group compared with the HRT group (OR: 1.54, 95% CI: 1.32-1.75, P < 0.001). There were no significant differences in the clinical pregnancy rate, embryo implantation rate, early miscarriage rate, or live birth rate between these two groups.ConclusionAlthough tamoxifen when used in combination with hormone replacement therapy can significantly increase endometrial thickness, it may not have a role in improving the pregnancy outcomes of patients with thin endometrium undergoing FET cycles.

【 授权许可】

Unknown   
Copyright © 2023 Shi, Huang, Liu, Li, Kong, Mei, Shen, Sun, Lu, Sun and Yan