The impact of adipose tissue distribution on endometrial cancer: a systematic review

Frontiers in Oncology

Oncology

Bjorn Winkens¹  Johanna M. A. Pijnenborg²  Louis J. M. van der Putten²  Anouk A. S. van denBosch³  Andrea Romano³  Henrica M. J. Werner³  Roy F. P. M. Kruitwagen³ 

[1] Department of Methodology and Statistics, Maastricht University, Maastricht, Netherlands;Department of Obstetrics and Gynaecology, Radboudumc, Nijmegen, Netherlands;Department of Obstetrics and Gynecology, GROW-School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, Netherlands;

关键词: endometrial cancer;    adipose tissue distribution;    prognosis;    obesity;    visceral adipose tissue;    subcutaneous adipose tissue;   

DOI  :  10.3389/fonc.2023.1182479

 received in 2023-03-08, accepted in 2023-05-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionEndometrial cancer (EC) is the most common gynecological cancer with a rising incidence, attributed to advanced life expectancy and obesity. Adipose tissue (AT) is an important endocrine organ, and its metabolic activity is affected by the different anatomical distribution or locations. AT distribution influences a number of diseases. In EC, it remains unclear whether the type of AT distribution affects development or prognosis. This systematic review aimed to determine whether AT distribution is associated with patient characteristics, disease characteristics, and patient prognosis in EC.Materials and methodsA search was conducted in Medline, MEDLINE EMBASE, and Cochrane Library. We included studies that enrolled patients with EC with any histological subtype and that distinguished between the visceral and subcutaneous AT compartment. In eligible studies, correlative analyses were performed for all outcome measures and AT distribution.ResultsEleven retrospective studies were included, with a wide range of measurements for the visceral and subcutaneous AT compartments. AT distribution was found to be significantly correlated to a number of relevant (disease) characteristics including obesity measures, histological subtype, lymph node metastasis, and sex steroid levels. Five studies reported on survival parameters including overall survival, progression-free survival and disease-specific survival, and they found that increased VAT volume was statistically significantly associated with a worse survival.Discussion/conclusionThis review demonstrates that there are significant correlations between AT distribution and prognosis, body mass index, sex steroid levels, and disease characteristics like histology. Well-designed, prospective, and larger-scale studies are needed to pinpoint these differences more specifically and understand how it can add in prediction and even therapy in EC.

【 授权许可】

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Copyright © 2023 Bosch, Pijnenborg, Romano, Winkens, Putten, Kruitwagen and Werner