Multi-omics analysis reveals the prognostic and tumor micro-environmental value of lumican in multiple cancer types

Frontiers in Molecular Biosciences

Molecular Biosciences

Zehuai Guo¹  Zeyun Li²  Ming Chen³  Yang Cao⁴  Xuenan Hou⁵  Zhe Sun⁵  Xiangjun Qi⁵  Siqi Wu⁵  Mengli Qiu⁵ 

[1] Department of Internal Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China;Guangzhou Huaxia Vocational College, Guangzhou, China;Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China;The First Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China;

关键词: lumican;    pan-cancer;    tumor microenvironment;    cancer-associated fibroblasts;    immunotherapy;    multi-omics;   

DOI  :  10.3389/fmolb.2023.1158747

 received in 2023-02-04, accepted in 2023-08-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background: Lumican (LUM), a proteoglycan of the extracellular matrix, has been reported to be involved in the regulation of immune escape processes, but the data supporting this phenomenon are not sufficient. In this study, we aimed to explore the links among LUM expression, survival, tumor microenvironment (TME), and immunotherapy in 33 cancer types.Methods: Data from several databases, such as UCSC Xena, GTEx, UALCAN, HPA, GEPIA2, TISIDB, PrognoScan, TIMER2, and GEO, as well as published studies, were used to determine the relationship between LUM expression and clinical features, TME, heterogeneity, and tumor stemness.Results: The expression of LUM was statistically different in most tumors versus normal tissues, both at the RNA and protein expression levels. High expression of LUM was typically associated with a poor prognosis in tumors. Additionally, immune scores, six immune cells, four immunosuppressive cells, cancer-associated fibroblasts (CAFs)-associated and immunosuppressive factors, tumor mutation burden (TMB), microsatellite instability (MSI), DNAss, and RNAss were all significantly associated with LUM. Among them, LUM expression displayed a significant positive correlation with CAFs and their factors, and exhibited immunosuppressive effects in six independent immunotherapy cohorts.Conclusion: Multi-omics analysis suggests that LUM may have been a prognostic marker, contributed to immunosuppression in the TME, and decreased the effectiveness of immune checkpoint inhibitors.

【 授权许可】

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Copyright © 2023 Guo, Li, Chen, Qi, Sun, Wu, Hou, Qiu and Cao.