Clinical, radiological and pathological features of temporomesial tumors in the adult. A single center experience from 15 years

Frontiers in Oncology

Oncology

Claire Delbridge¹  Benedikt Wiestler²  Lisa S. Hönikl³  Carl Ketterer³  Bernhard Meyer³  Jens Gempt⁴  Hanno S. Meyer⁴ 

[1] Department of Neuropathology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany;Department of Neuroradiology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany;Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany;Department of Neurosurgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany;Department of Neurosurgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany;Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

关键词: glioma;    glioblastoma;    temporal tumor;    brain tumor;    limbic encephalitis;    autoimmune encephalitis;   

DOI  :  10.3389/fonc.2023.1236269

 received in 2023-06-07, accepted in 2023-08-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionThe mesial temporal lobe plays a distinct role in epileptogenesis, and tumors in this part of the brain potentially have specific clinical and radiological features. Differentiating high-grade from lower-grade tumors or non-neoplastic lesions can be challenging, preventing the decision for early resection that can be critical in high-grade tumors.MethodsA brain tumor database was analyzed retrospectively to identify patients with temporomesial tumors. We determined clinical features (age, sex, symptoms leading to clinical presentation) as well as neuroradiological (tumor location and the presence of contrast enhancement on initial magnetic resonance imaging (MRI)) and neuropathological findings.ResultsWe identified 324 temporal tumors. 39 involved the mesial temporal lobe. 77% of temporomesial tumors occured in males, and 77% presented with seizures, regardless of tumor type or grade. In patients 50 years or older, 90% were male and 80% had glioblastoma (GBM); there was no GBM in patients younger than 50 years. 50% of GBMs lacked contrast enhancement. Male sex was significantly associated with GBM. In both contrast-enhancing and non-enhancing tumors, age of 50 years or older was also significantly associated with GBM.ConclusionIn middle-aged and older patients with a mesial temporal lobe tumor, GBM is the most likely diagnosis even when there is no MRI contrast enhancement. Prolonged diagnostic workup or surveillance strategies should be avoided and early resection may be justified in these patients.

【 授权许可】

Unknown   
Copyright © 2023 Meyer, Wiestler, Hönikl, Delbridge, Ketterer, Gempt and Meyer