Correlation between ADC, ADC ratio, and Gleason Grade group in prostate cancer patients undergoing radical prostatectomy: Retrospective multicenter study with different MRI scanners

Frontiers in Oncology

Oncology

Johan Bengtsson¹  Pia Charlotte Sundgren²  Erik Baubeta³  Sophia Zackrisson⁴  Erik Thimansson⁵  Despina Flondell-Sité⁶  Anders Bjartell⁶ 

[1] Department of Clinical Sciences, Radiology, Lund, Lund University, Lund, Sweden;Department of Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden;Department of Clinical Sciences, Radiology, Lund, Lund University, Lund, Sweden;Department of Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden;Lund Bioimaging Center (LBIC), Lund University, Lund, Sweden;Department of Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden;Department of Translational Medicine, Lund University, Malmö, Sweden;Department of Translational Medicine, Lund University, Malmö, Sweden;Department of Medical Imaging and Physiology, Skåne University Hospital, Malmö, Sweden;Department of Translational Medicine, Lund University, Malmö, Sweden;Department of Radiology, Helsingborg Hospital, Helsingborg, Sweden;Department of Translational Medicine, Lund University, Malmö, Sweden;Department of Urology, Skåne University Hospital, Malmö, Sweden;

关键词: MRI;    MR-diffusion;    ADC;    neoplasms;    prostate;   

DOI  :  10.3389/fonc.2023.1079040

 received in 2022-10-24, accepted in 2023-02-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundMRI is an important tool in the prostate cancer work-up, with special emphasis on the ADC sequence. This study aimed to investigate the correlation between ADC and ADC ratio compared to tumor aggressiveness determined by a histopathological examination after radical prostatectomy.MethodsNinety-eight patients with prostate cancer underwent MRI at five different hospitals prior to radical prostatectomy. Images were retrospectively analyzed individually by two radiologists. The ADC of the index lesion and reference tissues (contralateral normal prostatic, normal peripheral zone, and urine) was recorded. Absolute ADC and different ADC ratios were compared to tumor aggressivity according to the ISUP Gleason Grade Groups extracted from the pathology report using Spearman’s rank correlation coefficient (ρ). ROC curves were used to evaluate the ability to discriminate between ISUP 1-2 and ISUP 3-5 and intra class correlation and Bland-Altman plots for interrater reliability.ResultsAll patients had prostate cancer classified as ISUP grade ≥ 2. No correlation was found between ADC and ISUP grade. We found no benefit of using the ADC ratio over absolute ADC. The AUC for all metrics was close to 0.5, and no threshold could be extracted for prediction of tumor aggressivity. The interrater reliability was substantial to almost perfect for all variables analyzed.ConclusionsADC and ADC ratio did not correlate with tumor aggressiveness defined by ISUP grade in this multicenter MRI study. The result of this study is opposite to previous research in the field.

【 授权许可】

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Copyright © 2023 Bengtsson, Thimansson, Baubeta, Zackrisson, Sundgren, Bjartell and Flondell-Sité