Case report: Clinical characteristics of two cases of pneumonia caused with different strains of Chlamydia psittaci

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Hu Lu¹  Zheng Wang²  Li Wang²  Yan Tan²  Lin Gao²  Jing Zhang²  Chen Chen³  Lunbiao Cui⁴  Furong Du⁵  Chi Zhu⁵ 

[1]Department of Emergency, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China

[2]Department of Respiratory and Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China

[3]Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China

[4]NHC Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China

[5]State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co., Ltd., Nanjing, China

关键词: Chlamydia psittaci;    genotype;    clinical characteristics;    case report;    zoonosis;   

DOI  :  10.3389/fcimb.2023.1086454

 received in 2022-11-01, accepted in 2023-01-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundWith the development of metagenomic sequencing technologies, more and more cases of pneumonia caused with Chlamydia psittaci (C. psittaci) have been reported. However, it remains unknown about the characteristics of patients with pneumonia caused by different strains of C. psittaci. Here, we shared the clinical characteristics of two cases of pneumonia caused with C. psittaci strains SZ18-2 and SZ15 which were rarely identified in humans.Case presentationCase 1: A 69-year-old male farmer who fed ducks presented to hospital for cough, diarrhea and lethargy with the temperature of 39.8°C. Case 2: A 48-year-old male worker who slaughtered ducks was transferred to hospital for high fever, cough, myalgia, diarrhea and loss of appetite. Both patients did not take any protective measures (wearing face masks or gloves) while processing ducks. C. psittaci pneumonia was diagnosed by metagenomic next-generation sequencing and polymerase chain reaction. After treatment with doxycycline and azithromycin individually, they recovered well and discharged from hospital. Through OmpA sequencing, two different strains of SZ18-2 and SZ15 were identified in case 1 and case 2, respectively.ConclusionsPatients infected with different strains of C. psittaci may own different clinical manifestations. C. psittaci infection should be suspected when pneumonia appears, accompanied by digestive symptoms and multiple organ dysfunction, especially under the exposure of specific birds.

【 授权许可】

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Copyright © 2023 Wang, Chen, Lu, Wang, Gao, Zhang, Zhu, Du, Cui and Tan